Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer

• Published in: Cell proliferation Vol. 56; no. 10; p. e13478
• Main Authors: Wang, Ting, Ye, Zeng, Li, Zheng, Jing, De‐sheng, Fan, Gui‐xiong, Liu, Meng‐qi, Zhuo, Qi‐feng, Ji, Shun‐rong, Yu, Xian‐jun, Xu, Xiao‐wu, Qin, Yi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2023; John Wiley and Sons Inc
• Subjects: Chromatin; Disease; DNA methylation; Energy; Energy metabolism; Epigenetics; Gene expression; Glycolysis; Histones; Immune system; Kinases; Lactic acid; Metabolism; Mutation; Pancreatic cancer; Proteins; Review; Reviews; Tumor microenvironment; Tumorigenesis; Tumors
• ISSN: 0960-7722; 1365-2184; 1365-2184
• DOI: 10.1111/cpr.13478

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the role of a universal metabolic fuel for energy via the ‘lactate shuttle’ moving between cells and transmitting signals. The glycolytic‐dependent metabolism found in tumours and fast‐growing cells has made lact...