Substance P Neurokinin 1 Receptor Activation within the Dorsal Raphe Nucleus Controls Serotonin Release in the Mouse Frontal Cortex

• Published in: Molecular pharmacology Vol. 72; no. 6; pp. 1411 - 1418
• Main Authors: Guiard, Bruno P., Guilloux, Jean-Philippe, Reperant, Christelle, Hunt, Stephen P., Toth, Miklos, Gardier, Alain M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2007; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Frontal Lobe - metabolism; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Raphe Nuclei - drug effects; Raphe Nuclei - metabolism; Raphe Nuclei - physiology; Receptors, Neurokinin-1 - metabolism; Receptors, Neurokinin-1 - physiology; Serotonin - metabolism; Substance P - administration & dosage; Substance P - metabolism; Substance P - physiology

Preclinical studies suggest that substance P (SP) neurokinin 1 (NK1) receptor antagonists are efficient in the treatment of anxiety and depression. This therapeutic activity could be mediated via stimulation of serotonin (5-HT) neurons located in the dorsal raphe nucleus (DRN), which receive importa...