β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. 9; pp. 1289 - 1296
• Main Authors: Gitelman, Stephen E., Evans-Molina, Carmella, Guolo, Annamaria, Mari, Andrea, Ferrannini, Ele
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2023
• Subjects: Adolescent; Adolescents; Adult; Beta cells; Blood Glucose; Child; Clinical trials; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - drug therapy; Glucose; Humans; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - metabolism; Islet Studies; Remission; Secretion

Following a diagnosis of type 1 diabetes (T1D), persisting C-peptide secretion leads to improved glycemic control and outcomes. Residual β-cell function is often assessed with serial mixed-meal tolerance tests, but these tests do not correlate well with clinical outcomes. Herein, we instead use β-ce...