Susceptibility of aged mice to Staphylococcus aureus keratitis

• Published in: Current eye research Vol. 29; no. 4-5; pp. 269 - 275
• Main Authors: Girgis, Dalia, Sloop, Gregory, Reed, Julian, O'Callaghan, Richard
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.10.2004; Taylor & Francis
• Subjects: Aging; Animals; Colony Count, Microbial; Corneal Stroma - microbiology; Corneal Ulcer - microbiology; Corneal Ulcer - pathology; Disease Susceptibility; Eye Infections, Bacterial - microbiology; Eye Infections, Bacterial - pathology; keratitis; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils - enzymology; Neutrophils - immunology; Peroxidase - metabolism; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Staphylococcus aureus; Staphylococcus aureus - pathogenicity

Purpose. To determine the effect of age on the extent of pathogenesis of Staphylococcus keratitis in the mouse. Methods. Corneas of young and aged mice (BALB/c, A/J, and C57BL/6) were scarified and topically inoculated with S. aureus. Slit lamp examination (SLE) and histopathology were performed, an...