The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

• Published in: Fungal genetics and biology Vol. 169; p. 103836
• Main Authors: Karahoda, Betim, Pfannenstiel, Brandon T., Sarikaya-Bayram, Özlem, Dong, Zhiqiang, Ho Wong, Koon, Fleming, Alastair B., Keller, Nancy P., Bayram, Özgür
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2023
• Subjects: Aflatoxins - genetics; Aspergillus flavus; Chromatin - metabolism; Fungal Proteins - metabolism; Gene Expression Regulation, Fungal; Humans; Secondary Metabolism - genetics; Virulence

•KdmB-EcoA-RpdA-SntB complex was identified and characterized in A. flavus.•ecoA deletion is lethal whereas rpdA deletion is not lethal in A. flavus.•Similar to sntB, both kdmB and rpdA are essential for aflatoxin B1 production.•KERS is required for sclerotia formation, sporulation and expression of...