Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil

• Published in: The American journal of clinical nutrition Vol. 54; no. 1; pp. 104 - 110
• Main Authors: Wardlaw, GM, Snook, JT, Lin, MC, Puangco, MA, Kwon, JS
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1991; American Society for Clinical Nutrition
• Subjects: Adult; Analysis of Variance; Apolipoprotein A-I; Apolipoprotein B-100; apolipoproteins; Apolipoproteins - blood; Apolipoproteins A - blood; Apolipoproteins B - blood; Biological and medical sciences; Canola Oil; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Dietary Fats, Unsaturated - administration & dosage; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Unsaturated - administration & dosage; Fundamental and applied biological sciences. Psychology; HDL cholesterol; Humans; LDL cholesterol; Lipids - blood; Lipids. Glycolipids; Lipoproteins, HDL - blood; Male; Metabolisms and neurohumoral controls; Middle Aged; monounsaturated fatty acids; polyunsaturated fatty acids; Safflower Oil - administration & dosage; saturated fatty acids; Serum cholesterol; Single-Blind Method; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Serum cholesterol; apolipoproteins; polyunsaturated fatty acids; saturated fatty acids; LDL cholesterol; monounsaturated fatty acids; HDL cholesterol; Human; Rapeseed oil; Sunflower oil; Diet; Lipids; Apolipoproteins; Fatty acids; Cholesterol; Nutritional status; Comparative study
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/54.1.104

This randomized, blind study measured changes in serum lipid and apolipoprotein concentrations in 16 men consuming 39 ± 1% of energy (en%) as fat either from safflower- or canola-oil-based diets for 8 wk. Initially, the men were stabilized for 3 wk on a typical American (baseline) diet. Compared with baseline, the vegetable-oil-based diets reduced serum total cholesterol 9–15% (P< 0.002), low-density-lipo-protein (LDL)-cholesterol 12–20% (P< 0.002), and apolipoprotein B-100 21–24% (P< 0.001). There were no significant changes from baseline to the end of the study in serum triglycerides, total high-density-lipoprotein (HDL) cholesterol, HDL3cholesterol, HDL2cholesterol, or apolipoprotein A-I. These data suggest that even if total fat intake remains at 39–40 en%, many men show lowered LDL cholesterol if saturated fatty acid intake is minimized and that diets high in polyunsaturated fatty acids do not necessarily lower HDL-cholesterol concentrations.Am J Clin Nutr1991;54:104–10.