mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

• Published in: Cell reports (Cambridge) Vol. 5; no. 2; pp. 433 - 444
• Main Authors: Hartman, Nathaniel W., Lin, Tiffany V., Zhang, Longbo, Paquelet, Grace E., Feliciano, David M., Bordey, Angélique
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.10.2013; Elsevier
• Subjects: Animals; Carrier Proteins - metabolism; Cell Differentiation - drug effects; Cells, Cultured; Eukaryotic Initiation Factors - antagonists & inhibitors; Eukaryotic Initiation Factors - genetics; Eukaryotic Initiation Factors - metabolism; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins - antagonists & inhibitors; Monomeric GTP-Binding Proteins - genetics; Monomeric GTP-Binding Proteins - metabolism; Multiprotein Complexes - metabolism; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; Neuropeptides - antagonists & inhibitors; Neuropeptides - genetics; Neuropeptides - metabolism; Phosphoproteins - metabolism; Phosphorylation - drug effects; Ras Homolog Enriched in Brain Protein; Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors; Ribosomal Protein S6 Kinases, 90-kDa - genetics; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; RNA Interference; RNA, Small Interfering - metabolism; Sirolimus - pharmacology; TOR Serine-Threonine Kinases - metabolism

The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size. However, the function of mTORC1 on NSC self-renew...