Increased Cortical Thickness in Alzheimer's Disease

• Published in: Annals of neurology Vol. 95; no. 5; pp. 929 - 940
• Main Authors: Phan, Tony X., Baratono, Sheena, Drew, William, Tetreault, Aaron M., Fox, Michael D., Darby, R. Ryan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer's disease; Atrophy; Atrophy - pathology; Brain; Brain Cortical Thickness; Brain mapping; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cognitive ability; Cortex (cingulate); Cross-Sectional Studies; Dementia disorders; Female; Frontotemporal dementia; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - pathology; Humans; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Neurodegenerative diseases; Neuroimaging; Neuroplasticity; Signs and symptoms; Thickness; Visual cortex

Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in...