Deficit of pericapillary oligodendrocytes in the prefrontal cortex in schizophrenia

• Published in: The world journal of biological psychiatry Vol. 9; no. 1; pp. 34 - 42
• Main Authors: Vostrikov, Victor, Orlovskaya, Diana, Uranova, Natalya
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 2008; Taylor & Francis
• Subjects: Adult; Aged; Autopsy; Blood-Brain Barrier - physiology; Capillaries - metabolism; Capillaries - ultrastructure; Cause of Death; Cell Count; Cerebrovascular Circulation - physiology; Chronic Disease; Female; Humans; Male; Middle Aged; Oligodendroglia - metabolism; Oligodendroglia - ultrastructure; Pericapillary oligodendrocytes; Pilot Projects; prefrontal cortex; Prefrontal Cortex - blood supply; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Pyramidal Cells - metabolism; Pyramidal Cells - ultrastructure; schizophrenia; Schizophrenia - metabolism; Schizophrenia - pathology; Schizophrenia - physiopathology

Objective: Our previous studies have shown a significant decrease of numerical density of oligodendrocytes in the prefrontal cortex in postmortem schizophrenic brains. Deficit of oligodendrocytes was associated with loss of oligodendroglial satellites of pyramidal neurons. In this study we tested th...