Novel immunotherapies for the treatment of melanoma

• Published in: Immunotherapy Vol. 8; no. 5; pp. 613 - 632
• Main Authors: Gato-Cañas, Maria, Arasanz, Hugo, Blanco-Luquin, Idoia, Glaría, Estíbaliz, Arteta-Sanchez, Virginia, Kochan, Grazyna, Escors, David
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.05.2016
• Subjects: adoptive transfer; Animals; Antigen presentation; Apoptosis; cancer immunotherapy; Cancer therapies; Cytokines; Cytotoxicity; Dendritic cells; Disease Models, Animal; Genetic Engineering; Humans; Immune checkpoint; Immune system; Immunotherapy; Immunotherapy - methods; Immunotherapy - trends; Immunotherapy, Adoptive; Kinases; Lymphocyte Activation; Lymphocytes; Lymphoma; Melanoma; Melanoma - immunology; Melanoma - therapy; Molecular Targeted Therapy; Peptides; Proteins; Signal Transduction; T cell receptors; United States > US; melanoma; adoptive transfer; cancer immunotherapy
• ISSN: 1750-743X; 1750-7448
• DOI: 10.2217/imt-2015-0024

Immunotherapies are achieving clinical success for the treatment of many cancers. However, it has taken a long time to exploit the potential of the immune system for the treatment of human cancers. We cannot forget that this has been the consequence of very extensive work in basic research in preclinical models and in human patients. Thus, it is rather hard to compile all of it while giving a comprehensive view on this subject. Here we have attempted to give an overall perspective in immunotherapy of melanoma. A brief overview on current therapies is provided, followed by adoptive cell therapies. Gene engineering strategies to improve these therapies are also explained, finishing with therapies based on interference with immune checkpoint pathways.