Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and “omics” biomonitoring studies and possible mechanisms

• Published in: Mutation research Vol. 773; pp. 188 - 203
• Main Authors: Rossnerova, Andrea, Pokorna, Michaela, Svecova, Vlasta, Sram, Radim J., Topinka, Jan, Zölzer, Friedo, Rossner, Pavel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2017
• Subjects: Adaptation, Physiological - drug effects; Adaptation, Physiological - radiation effects; Adaptive response; Air Pollution - adverse effects; Benzo(a)pyrene - toxicity; Chromosome Aberrations - drug effects; Chromosome Aberrations - radiation effects; Cytogenetics; Czech Republic; DNA Damage - drug effects; DNA Damage - radiation effects; DNA methylation; DNA Methylation - drug effects; DNA Methylation - radiation effects; Environmental exposure; Environmental Monitoring; Humans; Micronuclei; Uranium - toxicity; X-Rays - adverse effects; PAR; PCBs; MTase; c-PAHs; WGBS; AS3MT; FG/100; FITC; DNA methylation; AHR2; KEGG; PBL; Cy-3; MN; Environmental exposure; CEN+MN; CEN-MN; Adaptive response; DAPI; 5mC; BER; PCA; XRCC SNP; BNC; Micronuclei; B[a]P; FISH; NHEJ; CBMN assay; MNNG

The human population is continually exposed to numerous harmful environmental stressors, causing negative health effects and/or deregulation of biomarker levels. However, studies reporting no or even positive impacts of some stressors on humans are also sometimes published. The main aim of this revi...