Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

• Published in: European neuropsychopharmacology Vol. 42; pp. 1 - 11
• Main Authors: Donovan, Lene Lundgaard, Johansen, Jens Vilstrup, Ros, Nídia Fernandez, Jaberi, Elham, Linnet, Kristian, Johansen, Sys Stybe, Ozenne, Brice, Issazadeh-Navikas, Shohreh, Hansen, Hanne Demant, Knudsen, Gitte Moos
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021
• Subjects: 5-HT2A receptor; Behaviour; Brain; Gene expression; Immune response; Psychedelic; Brain; 5-HT2A receptor; Immune response; Behaviour; Gene expression; Psychedelic

•Pigs respond to 0.08 mg/kg psilocybin i.v. with headshakes, scratching and rubbing behaviour.•A similar dose produce a cerebral 5-HT2A receptor occupancy of ~67%.•1 week after psilocybin exposure an immunology-related genetic response was seen in prefrontal cortex. Psilocybin has in some studies sh...