The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

• Published in: Experimental and molecular pathology Vol. 129; p. 104846
• Main Authors: Goyal, Ahsas, Agrawal, Anant, Verma, Aanchal, Dubey, Nandini
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2023
• Subjects: Aged; AKT; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Humans; Neurodegeneration; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neuroprotective Agents - metabolism; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Parkinson Disease - drug therapy; Parkinsonism; Phosphatidylinositol 3-Kinases - metabolism; PI3K; Proto-Oncogene Proteins c-akt - metabolism; Signaling pathway; Parkinsonism; AKT; Signaling pathway; PI3K; Neurodegeneration

Parkinson's disease is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis a...