Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats

• Published in: The Journal of immunology (1950) Vol. 159; no. 1; pp. 466 - 471
• Main Authors: Chung, YH, Jun, HS, Kang, Y, Hirasawa, K, Lee, BR, Van Rooijen, N, Yoon, JW
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.07.1997
• Subjects: Animals; Breeding; Cytokines - immunology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - virology; Kilham rat virus; Macrophage Activation - immunology; Macrophages - immunology; Parvovirus; Rats

The diabetes-resistant BioBreeding (DR-BB) rat, derived from diabetes-prone forebears, does not normally develop spontaneous insulitis or diabetes, but when infected with Kilham rat virus (KRV) this animal develops autoimmune diabetes similar to the diabetes-prone BioBreeding (DP-BB) rat. In this st...