The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites - Pratt, Susan; Shepard, Robert L.; Kandasamy, Ramani A.; Johnston, Paul A.; Perry, William; Dantzig, Anne H. (Molecular cancer therapeutics, 2005)
Keywords: 5-fluorouracil; Adenosine Triphosphate - pharmacology; Antimetabolites, Antineoplastic - pharmacokinetics; Antimetabolites, Antineoplastic - pharmacology; Apoptosis - drug effects; Biological Transport - drug effects; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Floxuridine - metabolism; Fluorouracil - pharmacokinetics; Fluorouracil - pharmacology; Humans; Kidney - cytology; Kidney - drug effects; Kidney - metabolism; Metabolites; MRP-5 (ABCC5); Multidrug resistance protein; Multidrug Resistance-Associated Proteins - metabolism; Phosphorylation - drug effects; Thioguanine - pharmacology; Thymidylate Synthase - metabolism