Insights into the relationship between persistent antibody secretion and metabolic programming – A question for single-cell analysis

Vaccination aims to generate a protective and persisting antibody response. Indeed, humoral vaccine-mediated protection depends on the quality and quantity of the produced antigen-specific antibodies for its initial magnitude and the persistence of the plasma cells for its duration. Therefore, under...

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Bibliographic Details
Published inImmunology letters Vol. 260; pp. 35 - 43
Main Authors Bucheli, Olivia T.M., Eyer, Klaus
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2023
Subjects
Antibody-secreting cells
Durable immunity
Immunometabolism
Metabolic profiling
Metabolism
Plasma cells
2-NBDG
TCR
RNA
OXPHOS
IL-R
mRNA
Metabolic profiling
scRNA-seq
UPR
MIBI-TOF
TLR
GC
CD
MSI
CSR
MS
TCA cycle
Durable immunity
scMEP
Metabolism
ER
Antibody-secreting cells
BCR
Immunometabolism
ROS
Plasma cells
ATP
mTORC1
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Summary:Vaccination aims to generate a protective and persisting antibody response. Indeed, humoral vaccine-mediated protection depends on the quality and quantity of the produced antigen-specific antibodies for its initial magnitude and the persistence of the plasma cells for its duration. Therefore, understanding the mechanisms behind the generation, selection and maintenance of long-lived plasma cells secreting protective antibodies is of fundamental importance for understanding long-term immunity, vaccine responses, therapeutical approaches for autoimmune disease and multiple myeloma. Recent studies have observed correlations between the generation, function and lifespan of plasma cells and their metabolism, with metabolism being both a main driver and primary consequence of changes in cellular behavior. This review introduces how metabolic programs influence and drive immune cell functions in general and plasma cell differentiation and longevity more specifically, summarizing the current knowledge on metabolic pathways and their influences on cellular fate. In addition, available technologies to profile metabolism and their limitations are discussed, leading to the unique and open technological challenges for further advancement of this research field. [Display omitted]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2023.06.006