Interleukin-21: biology and application to cancer therapy

• Published in: Expert opinion on biological therapy Vol. 8; no. 9; p. 1295
• Main Authors: Andorsky, David J, Timmerman, John M
• Format: Journal Article
• Language: English
• Published: England 01.09.2008
• Subjects: Animals; Clinical Trials as Topic; Disease Models, Animal; Humans; Interleukins - genetics; Interleukins - metabolism; Interleukins - physiology; Interleukins - therapeutic use; Lymphocytes - metabolism; Mice; Neoplasms - drug therapy; Receptors, Interleukin-21 - metabolism; Recombinant Proteins - metabolism; Recombinant Proteins - therapeutic use

IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms. In addition, IL-21...