Multiomics Analyses With Stool-Type Stratification in Patient Cohorts and Blautia Identification as a Potential Bacterial Modulator in Type 2 Diabetes Mellitus

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. 3; pp. 511 - 527
• Main Authors: Guo, Qian, Gao, Zezheng, Zhao, Linhua, Wang, Han, Luo, Zhen, Vandeputte, Doris, He, Lisha, Li, Mo, Di, Sha, Liu, Yanwen, Hou, Jiaheng, Jiang, Xiaoqing, Zhu, Huaiqiu, Tong, Xiaolin
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.03.2024
• Subjects: Animal research; Association analysis; Bacteria; Biological analysis; Blautia; Diabetes; Diabetes mellitus (non-insulin dependent); Dietary supplements; Genetics/Genomes/Proeomics/Metabolomics; Insulin secretion; Intestinal microflora; Metabolic disorders; Metabolism; Metabolites; Microbiomes; Microbiota; Microenvironments; Patients; Phenotypes; Transcriptomes

Heterogeneity in host and gut microbiota hampers microbial precision intervention of type 2 diabetes mellitus (T2DM). Here, we investigated novel features for patient stratification and bacterial modulators for intervention, using cross-sectional patient cohorts and animal experiments. We collected...