NK-KIR ligand identification: a quick Q-PCR approach for HLA-C epitope typing

• Published in: Tissue antigens Vol. 69; no. 4; pp. 334 - 337
• Main Authors: Schellekens, J., Rozemuller, E. H., Borst, H. P. E., Otten, H. G., Van Den Tweel, J. G., Tilanus, M. G. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2007
• Subjects: Alleles; DNA Primers - chemistry; Epitopes - genetics; Histocompatibility; Histocompatibility Testing - methods; HLA Antigens - genetics; HLA-C Antigens - biosynthesis; HLA-C Antigens - genetics; HLA-C epitope; Homozygote; Humans; Killer Cells, Natural - cytology; KIR; KIR ligand; Ligands; Polymerase Chain Reaction - methods; Q-PCR

Interaction of donor natural killer (NK)‐cell‐associated killer cell immunoglobulin‐like receptors (KIRs) with the patient’s human leukocyte antigen‐C (HLA‐C) ligands can result in an alloreactive NK response after haematopoietic stem cell transplantation. In many retrospective studies, additional H...