Analysis and bioequivalency study on two tablet formulations of co-trimoxazole

• Published in: Journal of clinical pharmacy and therapeutics Vol. 18; no. 2; p. 109
• Main Authors: Sheikh Salem, M, Alkaysi, H N, Gharaibeh, A M, Amari, F F, Sallam, E, Shubair, M S
• Format: Journal Article
• Language: English
• Published: England 01.04.1993
• Subjects: Biological Availability; Chromatography, High Pressure Liquid - methods; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Tablets; Therapeutic Equivalency; Trimethoprim, Sulfamethoxazole Drug Combination - blood; Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics

This paper describes an analytical procedure for simultaneous quantification of trimethoprim (TMP) and sulphamethoxazole (SMZ) in serum. Serum samples were rendered alkaline with glycine-sodium hydroxide buffer (pH 9.1) and extracted with ethyl acetate. The reconstituted sample was analysed using re...