Investigation into the potential mechanism and therapeutic targets of Cangzhu Erchen decoction for the treatment of chronic obstructive pulmonary disease based on bioinformatics and network pharmacology

• Published in: Medicine (Baltimore) Vol. 103; no. 33; p. e39338
• Main Authors: Gu, Xiaofei, Ju, Jiangang, Chen, Qingqing, Ge, Minjie, Huang, Huaqiong
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 16.08.2024
• Subjects: Computational Biology - methods; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Humans; Medicine, Chinese Traditional - methods; Molecular Docking Simulation; Network Pharmacology; Observational Study; Protein Interaction Maps; Pulmonary Disease, Chronic Obstructive - drug therapy; molecular docking; potential mechanism; Cangzhu Erchen decoction; network pharmacology; chronic obstructive pulmonary disease

This study aimed to elucidate the molecular mechanisms underlying the therapeutic effects of Cangzhu Erchen decoction (CZECD) in the treatment of chronic obstructive pulmonary disease (COPD) using microarray analysis, network pharmacology, and molecular docking. The active components and candidate t...