A PadR family transcriptional repressor controls transcription of a trivalent metalloid resistance operon of Azospirillum halopraeferens strain Au 4

• Published in: Environmental microbiology Vol. 24; no. 11; pp. 5139 - 5150
• Main Authors: Zhang, Jun, Wu, Yi‐Fei, Tang, Shi‐Tong, Chen, Jian, Rosen, Barry P., Zhao, Fang‐Jie
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2022; Wiley Subscription Services, Inc
• Subjects: Antibiotics; Arsenic; Arsenic - metabolism; Arsenite; arsenites; Azospirillum; Azospirillum halopraeferens; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Binding sites; cysteine; Electrophoretic mobility; Gene Expression Regulation, Bacterial; Genes; ligands; Metalloids; Metalloids - metabolism; microbiology; Mutation; Nucleotide sequence; Operon; promoter regions; Promoters; Recombinants; repressor proteins; reverse transcriptase polymerase chain reaction; RNA-directed DNA polymerase; Serine; Stibnite; toxicity; Transcription; transcription (genetics); Transcription Factors - genetics; Transcription Factors - metabolism

Methylarsenite [MAs(III)] is a highly toxic arsenical produced by some microbes as an antibiotic. In this study, we demonstrate that a PadR family transcriptional regulator, PadRars, from Azospirillum halopraeferens strain Au 4 directly binds to the promoter region of the arsenic resistance (ars) op...