Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotoxic activity

The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pressure to yield residue,which was suspended i...

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Published inJournal of pharmaceutical analysis Vol. 1; no. 1; pp. 57 - 59
Main Authors He, Yang-Qing, Yao, Bing-Hua, Ma, Zhan-Ying
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.02.2011
Xi'an Jiaotong University
Elsevier
Subjects
Aconitum richardsonianum var. pseudosessiliflorum
cytotoxic activity
diterpene alkaloids
Original article
Ranunculaceae
Sephadex
VAR
乌头
乙醇提取
二萜生物碱
细胞毒活性
药用植物
藏族
Aconitum richardsonianum var. pseudosessiliflorum
cytotoxic activity
diterpene alkaloids
Ranunculaceae
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Summary:The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pressure to yield residue,which was suspended in water and successively partitioned with chloroform.The chloroform extraction was isolated and purified by silica gel and Sephadex LH-20 column chromatography.Six compounds were isolated and elucidated as delelatine（1）,isodelpheline（2）,3-acetylaconitine（3）,isoatisine（4）,nordhagenine A（5）and yunaconitine（6）.Compounds 1-5 were obtained from Aconitum Brunneum for the first time.Compound（1）showed significant cytotoxic activities（IC50=4.36 μM）against the human tumor cell line P388.
Bibliography:61-1484/R
The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pressure to yield residue,which was suspended in water and successively partitioned with chloroform.The chloroform extraction was isolated and purified by silica gel and Sephadex LH-20 column chromatography.Six compounds were isolated and elucidated as delelatine（1）,isodelpheline（2）,3-acetylaconitine（3）,isoatisine（4）,nordhagenine A（5）and yunaconitine（6）.Compounds 1-5 were obtained from Aconitum Brunneum for the first time.Compound（1）showed significant cytotoxic activities（IC50=4.36 μM）against the human tumor cell line P388.
Aconitum richardsonianum var.pseudosessiliflorum;Ranunculaceae;diterpene alkaloids;cytotoxic activity
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2095-1779
2214-0883
DOI:10.1016/S2095-1779(11)70010-7