Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease

• Published in: Annals of neurology Vol. 28; no. 2; p. 157
• Main Authors: Beal, M F, MacGarvey, U, Swartz, K J
• Format: Journal Article
• Language: English
• Published: United States 01.08.1990
• Subjects: Aged; Alzheimer Disease - metabolism; Amino Acids - analysis; Catecholamines - analysis; Choline O-Acetyltransferase - analysis; Female; Galanin; Humans; Male; Neuropeptides - analysis; Neurotransmitter Agents - analysis; Peptides - analysis; Radioimmunoassay; Substantia Innominata - chemistry

A depletion of large cholinergic neurons in the nucleus basalis of Meynert is a consistent finding in Alzheimer's disease (AD). The nucleus basalis of Meynert also contains interneurons and afferents that may modulate its functioning. In the present study we examined neurochemical markers for n...