Nodal Yield From Neck Dissection Predicts the Anti‐Tumor Immune Response in Head and Neck Cancers

• Published in: Head & neck Vol. 47; no. 4; pp. 1199 - 1208
• Main Authors: Chen, Shuqing, Pyne, Justin M., Liu, Yulun, Abraham, Youstina, Wen, Zhuoyu, Palsgrove, Doreen, Xiao, Guanghua, Truelson, John, Myers, Larry, Tillman, Brittny, Day, Andrew, Gordin, Eli, Stankova, Lenka, Xie, Yang, Sher, David, Bishop, Justin, Gao, Jinming, Sumer, Baran D.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2025; Wiley Subscription Services, Inc
• Subjects: Aged; Body Mass Index; Cancer; Case-Control Studies; CD20 antigen; CD3 antigen; CD8 antigen; Dissection; Female; Head & neck cancer; head and neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - surgery; Humans; Immune response; Immune status; Immunohistochemistry; Immunosuppression; Kaplan-Meier Estimate; Leukocytes; lymph node; Lymph Node Ratio - statistics & numerical data; Lymph nodes; Lymph Nodes - immunology; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphocytes; Lymphocytes, Tumor-Infiltrating - immunology; Male; Malnutrition - etiology; Malnutrition - immunology; Malnutrition - mortality; Metastases; Middle Aged; Neck; Neck Dissection - methods; Neck Dissection - statistics & numerical data; Original; Patients; Retrospective Studies; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - immunology; Squamous Cell Carcinoma of Head and Neck - mortality; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - surgery; Statistical analysis; survival; Tumors; Undernutrition; immune status; head and neck cancer; body mass index; lymph node; survival

ABSTRACT Background Lymph node count (LNC) from neck dissection has been associated with undernutrition and survival in head and neck squamous cell carcinoma (HNSCC). As local components of the immune system, cervical lymph nodes may reflect anti‐tumor immune status. This study investigates the rela...