Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease - Rolan, Paul; Seckl, Jonathan; Taylor, Jack; Harrison, John; Maruff, Paul; Woodward, Michael; Mills, Richard; Jaros, Mark; Hilt, Dana (Clinical pharmacology in drug development, 2025)
Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors; 11β‐HSD1; Alzheimer disease; Alzheimer Disease - drug therapy; Brain - diagnostic imaging; Brain - drug effects; Brain - metabolism; Central Nervous System Diseases - drug therapy; Cognition - drug effects; cognitive enhancement; cognitive test battery; cortisol; Dose-Response Relationship, Drug; dose‐finding; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - pharmacology; Humans; Hydrocortisone - biosynthesis; Models, Biological; PET; Positron-Emission Tomography; 11β‐HSD1; cognitive test battery; cortisol; Alzheimer disease; dose‐finding; cognitive enhancement; PET