A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val66Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects

• Published in: PloS one Vol. 11; no. 10; p. e0162585
• Main Authors: Latsko, Maeson S., Gilman, T. Lee, Matt, Lindsey M., Nylocks, K. Maria, Coifman, Karin G., Jasnow, Aaron M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2016; Public Library of Science (PLoS)
• Subjects: Adults; Affective Symptoms - genetics; Alleles; Amino Acid Substitution - genetics; Amino Acid Substitution - physiology; Animal models; Anxiety; Behavior; Biology and Life Sciences; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - physiology; Carriers; Disorders; Ecological monitoring; Emotions; Epistasis; Epistasis, Genetic - genetics; Female; Gene expression; Gene polymorphism; Gene regulation; Genetic Association Studies; Genotypes; Health risks; Humans; Influence; Inhibition; Inhibition (Psychology); Male; Medicine and Health Sciences; Mental depression; Mental disorders; Microprocessors; Neurosciences; Polymorphism; Polymorphism, Restriction Fragment Length - genetics; Polymorphism, Single Nucleotide - genetics; Polymorphism, Single Nucleotide - physiology; Research and Analysis Methods; Rigidity; Risk Factors; Risk perception; Rodents; Serotonin; Social Sciences; Stress; Stroop Test; Studies; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - physiology; Young Adult

Poor inhibitory processing of negative emotional content is central to many psychiatric disorders, including depression and anxiety. Moreover, increasing evidence suggests that core aspects of emotion-inhibitory processing are largely inherited and as such may represent a key intermediate or risk-re...