Prediagnostic levels of C‐peptide, IGF‐I, IGFBP ‐1, ‐2 and ‐3 and risk of endometrial cancer

• Published in: International journal of cancer Vol. 108; no. 2; pp. 262 - 268
• Main Authors: Lukanova, Annekatrin, Zeleniuch‐Jacquotte, Anne, Lundin, Eva, Micheli, Andrea, Arslan, Alan A., Rinaldi, Sabina, Muti, Paola, Lenner, Per, Koenig, Karen L., Biessy, Carine, Krogh, Vittorio, Riboli, Elio, Shore, Roy E., Stattin, Par, Berrino, Franco, Hallmans, Göran, Toniolo, Paolo, Kaaks, Rudolf
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 10.01.2004; Wiley-Liss
• Subjects: Adult; Aged; Biological and medical sciences; Biomarkers, Tumor - blood; C-peptide; C-Peptide - blood; Case-Control Studies; Chronic Disease; Cohort Studies; cohort study; endometrial cancer; Endometrial Neoplasms - blood; Endometrial Neoplasms - diagnosis; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Hyperinsulinism - blood; Insulin - metabolism; Insulin-Like Growth Factor Binding Protein 1 - blood; Insulin-Like Growth Factor Binding Protein 2 - blood; Insulin-Like Growth Factor Binding Protein 3 - blood; insulin-like growth factor binding proteins; Insulin-Like Growth Factor I - metabolism; insulin-like growth factor-I; Medical sciences; MEDICIN; MEDICINE; Middle Aged; Prognosis; Prospective Studies; Risk Factors; Tumors; Italy; Sweden; United States; North America; Europe; America; Human; Endometrium cancer; Peptides; Malignant tumor; Case control study; Insulin like growth factor 1; Epidemiology; C-Peptide; Female genital diseases; Polypeptide; Insulin like growth factor binding protein 1; Cohort study; Risk factor; Uterine diseases; Public health; Growth factor

Conditions related to chronic hyperinsulinemia, such as obesity, noninsulin dependent diabetes mellitus and polycystic ovary syndrome, are associated with an increased risk of endometrial cancer. Elevated plasma IGF‐I and decreased levels of IGF‐binding proteins have been shown to be associated with...