Causal relationship between 41 inflammatory factors, circulating white blood cells, and pruritus: A 2-sample bidirectional Mendelian randomization study

• Published in: Medicine (Baltimore) Vol. 103; no. 50; p. e40894
• Main Authors: Zheng, Kaiyuan, Wang, Siyu, Zeng, Lianlin, Li, Yangan, Hu, Kehui
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 13.12.2024
• Subjects: Cytokines - blood; Cytokines - genetics; Humans; Leukocyte Count; Leukocytes - metabolism; Mendelian Randomization Analysis; Observational Study; Pruritus - blood; Pruritus - etiology; Pruritus - genetics; pruritus; Mendelian randomization; causal relationship; inflammatory factors; circulating white blood cell
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000040894

The influence of circulating white blood cells and inflammatory factors on pruritus is gradually recognized by the public, but the specific causal relationship is still unknown. In this study, we included inflammatory cytokine profiles from 8293 healthy subjects, genetic data on blood cells from var...