Nicorandil treatment improves survival and spatial learning in aged granulin knockout mice

• Published in: Brain pathology (Zurich, Switzerland) Vol. 35; no. 3; pp. e13312 - n/a
• Main Authors: Niedowicz, Dana M., Wang, Wang‐Xia, Prajapati, Paresh, Zhong, Yu, Fister, Shuling, Rogers, Colin B., Sompol, Pradoldej, Powell, David K., Patel, Indumati, Norris, Christopher M., Saatman, Kathryn E., Nelson, Peter T.
• Format: Journal Article
• Language: English
• Published: Switzerland John Wiley & Sons, Inc 01.05.2025; John Wiley and Sons Inc
• Subjects: Aging; Animals; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Cognition; Dementia; Dementia disorders; Disease Models, Animal; Drinking water; Encephalopathy; Female; Frontotemporal dementia; FTLD‐TDP; Gene expression; Glial fibrillary acidic protein; Gliosis; Granulin; Granulins - genetics; Inflammation; KATP; LATE‐NC; Male; Maze Learning - drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal-glial interactions; Nicorandil - pharmacology; Nicorandil - therapeutic use; progranulin; Progranulins; Spatial discrimination learning; Spatial Learning - drug effects; SUR2; Survival; TDP‐43; progranulin; KATP; LATE‐NC; SUR2; TDP‐43; FTLD‐TDP

Mutations in the human granulin (GRN) gene are associated with multiple diseases, including dementia disorders such as frontotemporal dementia (FTD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE). We studied a Grn knockout (Grn‐KO) mouse model in order to evaluate a potential therap...