Time Course of Reversal of Fentanyl‐Induced Respiratory Depression in Healthy Subjects by Intramuscular Nalmefene and Intramuscular and Intranasal Naloxone - Cipriano, Alessandra; Apseloff, Glen; Kapil, Ram P.; He, Ellie; Shet, Manjunath; Harris, Stephen C. (Journal of clinical pharmacology, 2025)
Keywords: Administration, Intranasal; Adult; Analgesics, Opioid - adverse effects; Cross-Over Studies; Female; fentanyl; Fentanyl - adverse effects; Healthy Volunteers; Humans; Injections, Intramuscular; Male; Middle Aged; nalmefene; naloxone; Naloxone - administration & dosage; Naloxone - adverse effects; Naloxone - pharmacokinetics; Naltrexone - administration & dosage; Naltrexone - adverse effects; Naltrexone - analogs & derivatives; Naltrexone - pharmacokinetics; Narcotic Antagonists - administration & dosage; Narcotic Antagonists - adverse effects; Narcotic Antagonists - pharmacokinetics; opioid antagonist; opioid overdose; pharmacodynamics; pharmacokinetics; respiratory depression reversal; Respiratory Insufficiency - chemically induced; Respiratory Insufficiency - drug therapy; Young Adult; opioid antagonist; opioid overdose; pharmacodynamics; fentanyl; pharmacokinetics; naloxone; nalmefene; respiratory depression reversal