A Phase 1 Study to Evaluate the Pharmacokinetic Drug‐Drug Interaction Between Islatravir and Methadone in Participants on Stable Methadone Therapy - Matthews, Randolph P.; Ankrom, Wendy; Handy, Whitney; Patel, Munjal; Matthews, Catherine; Xu, Zhiqing; Gravesande, Kezia; Searle, Shawn; Schwartz, Howard; Stoch, S. Aubrey; Iwamoto, Marian (Clinical pharmacology in drug development, 2025)
Keywords: Adult; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - pharmacokinetics; Area Under Curve; clinical pharmacology; coadministration; Drug Interactions; Female; HIV Infections - drug therapy; human immunodeficiency virus; Humans; Male; Methadone - administration & dosage; Methadone - blood; Methadone - pharmacokinetics; Middle Aged; nucleoside reverse transcriptase translocation inhibitor; Opiate Substitution Treatment - methods; people who inject drugs; Reverse Transcriptase Inhibitors - administration & dosage; Reverse Transcriptase Inhibitors - adverse effects; Reverse Transcriptase Inhibitors - pharmacokinetics; human immunodeficiency virus; clinical pharmacology; nucleoside reverse transcriptase translocation inhibitor; coadministration; people who inject drugs