Characterisation of GPR17‐expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses

• Published in: The Journal of pathology Vol. 265; no. 2; pp. 226 - 243
• Main Authors: Raffaele, Stefano, Clausen, Bettina Hjelm, Mannella, Francesca Carolina, Wirenfeldt, Martin, Marangon, Davide, Tidgen, Sarah Boe, Corradini, Silvia, Madsen, Kirsten, Lecca, Davide, Abbracchio, Maria Pia, Lambertsen, Kate Lykke, Fumagalli, Marta
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2025; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Astrocytes; Brain injury; Brain Ischemia - metabolism; Brain Ischemia - pathology; Breast cancer; Breast carcinoma; Cell Differentiation; Cell surface receptors; Demyelination; Female; glial cell interactions; Glial cells; Glial stem cells; GPR17 receptor; Humans; Immunohistochemistry; ischaemic stroke; Ischemia; Ischemic Stroke - metabolism; Ischemic Stroke - pathology; Macrophages; Male; Microglia; Microglia - metabolism; Microglia - pathology; Middle Aged; Myelin; Myelination; Neuroglia - metabolism; Neuroglia - pathology; neuroinflammation; oligodendrocyte precursor cells; Oligodendrocyte Precursor Cells - metabolism; Oligodendrocyte Precursor Cells - pathology; Oligodendrocytes; Oligodendroglia - metabolism; Oligodendroglia - pathology; Original; Phagocytes; Phenotypes; post‐mortem brain tissue; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; remyelination; Stroke; Substantia alba; Transcriptomics; oligodendrocyte precursor cells; ischaemic stroke; glial cell interactions; neuroinflammation; oligodendrocytes; GPR17 receptor; astrocytes; microglia; post‐mortem brain tissue; remyelination

White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligod...