Characterisation of GPR17‐expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses
White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligod...
Saved in:
| Published in | The Journal of pathology Vol. 265; no. 2; pp. 226 - 243 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.02.2025
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein‐coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke. To determine the translational value of GPR17 as a possible target in the context of human disease, we exploited immunohistochemistry to characterise the distribution of GPR17‐expressing cells in brain tissue samples from ischaemic stroke cases and correlated it with the reactive state of neighbouring glial cells. The results showed that GPR17 specifically decorates a subpopulation of differentiation‐committed OPCs, labelled by the peculiar marker breast carcinoma‐amplified sequence 1 (BCAS1), that accumulates in the peri‐infarct region in the later stages after the ischaemic event. Interestingly, the response of GPR17‐expressing cells appears to be paralleled by the switch of reactive microglia/macrophages from a phagocytic to a dystrophic phenotype and by astrocytic scar formation. A negative correlation was found between GPR17‐expressing OPCs and reactive microglia/macrophages and astrocytes surrounding chronic ischaemic lesions in female subjects, while the same relationship was less pronounced in males. These results were reinforced by bioinformatic analysis of a publicly available transcriptomic dataset, which implicated a possible role of inflammation and defective neuron‐to‐OPC communication in remyelination failure after ischaemic damage. Hence, these data strengthen the relevance of GPR17‐based remyelinating therapies for the treatment of ischaemic stroke. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. |
|---|---|
| AbstractList | White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein‐coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke. To determine the translational value of GPR17 as a possible target in the context of human disease, we exploited immunohistochemistry to characterise the distribution of GPR17‐expressing cells in brain tissue samples from ischaemic stroke cases and correlated it with the reactive state of neighbouring glial cells. The results showed that GPR17 specifically decorates a subpopulation of differentiation‐committed OPCs, labelled by the peculiar marker breast carcinoma‐amplified sequence 1 (BCAS1), that accumulates in the peri‐infarct region in the later stages after the ischaemic event. Interestingly, the response of GPR17‐expressing cells appears to be paralleled by the switch of reactive microglia/macrophages from a phagocytic to a dystrophic phenotype and by astrocytic scar formation. A negative correlation was found between GPR17‐expressing OPCs and reactive microglia/macrophages and astrocytes surrounding chronic ischaemic lesions in female subjects, while the same relationship was less pronounced in males. These results were reinforced by bioinformatic analysis of a publicly available transcriptomic dataset, which implicated a possible role of inflammation and defective neuron‐to‐OPC communication in remyelination failure after ischaemic damage. Hence, these data strengthen the relevance of GPR17‐based remyelinating therapies for the treatment of ischaemic stroke. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein-coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke. To determine the translational value of GPR17 as a possible target in the context of human disease, we exploited immunohistochemistry to characterise the distribution of GPR17-expressing cells in brain tissue samples from ischaemic stroke cases and correlated it with the reactive state of neighbouring glial cells. The results showed that GPR17 specifically decorates a subpopulation of differentiation-committed OPCs, labelled by the peculiar marker breast carcinoma-amplified sequence 1 (BCAS1), that accumulates in the peri-infarct region in the later stages after the ischaemic event. Interestingly, the response of GPR17-expressing cells appears to be paralleled by the switch of reactive microglia/macrophages from a phagocytic to a dystrophic phenotype and by astrocytic scar formation. A negative correlation was found between GPR17-expressing OPCs and reactive microglia/macrophages and astrocytes surrounding chronic ischaemic lesions in female subjects, while the same relationship was less pronounced in males. These results were reinforced by bioinformatic analysis of a publicly available transcriptomic dataset, which implicated a possible role of inflammation and defective neuron-to-OPC communication in remyelination failure after ischaemic damage. Hence, these data strengthen the relevance of GPR17-based remyelinating therapies for the treatment of ischaemic stroke. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein-coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke. To determine the translational value of GPR17 as a possible target in the context of human disease, we exploited immunohistochemistry to characterise the distribution of GPR17-expressing cells in brain tissue samples from ischaemic stroke cases and correlated it with the reactive state of neighbouring glial cells. The results showed that GPR17 specifically decorates a subpopulation of differentiation-committed OPCs, labelled by the peculiar marker breast carcinoma-amplified sequence 1 (BCAS1), that accumulates in the peri-infarct region in the later stages after the ischaemic event. Interestingly, the response of GPR17-expressing cells appears to be paralleled by the switch of reactive microglia/macrophages from a phagocytic to a dystrophic phenotype and by astrocytic scar formation. A negative correlation was found between GPR17-expressing OPCs and reactive microglia/macrophages and astrocytes surrounding chronic ischaemic lesions in female subjects, while the same relationship was less pronounced in males. These results were reinforced by bioinformatic analysis of a publicly available transcriptomic dataset, which implicated a possible role of inflammation and defective neuron-to-OPC communication in remyelination failure after ischaemic damage. Hence, these data strengthen the relevance of GPR17-based remyelinating therapies for the treatment of ischaemic stroke. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein‐coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke. To determine the translational value of GPR17 as a possible target in the context of human disease, we exploited immunohistochemistry to characterise the distribution of GPR17‐expressing cells in brain tissue samples from ischaemic stroke cases and correlated it with the reactive state of neighbouring glial cells. The results showed that GPR17 specifically decorates a subpopulation of differentiation‐committed OPCs, labelled by the peculiar marker breast carcinoma‐amplified sequence 1 (BCAS1), that accumulates in the peri‐infarct region in the later stages after the ischaemic event. Interestingly, the response of GPR17‐expressing cells appears to be paralleled by the switch of reactive microglia/macrophages from a phagocytic to a dystrophic phenotype and by astrocytic scar formation. A negative correlation was found between GPR17‐expressing OPCs and reactive microglia/macrophages and astrocytes surrounding chronic ischaemic lesions in female subjects, while the same relationship was less pronounced in males. These results were reinforced by bioinformatic analysis of a publicly available transcriptomic dataset, which implicated a possible role of inflammation and defective neuron‐to‐OPC communication in remyelination failure after ischaemic damage. Hence, these data strengthen the relevance of GPR17‐based remyelinating therapies for the treatment of ischaemic stroke. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. |
| Author | Clausen, Bettina Hjelm Tidgen, Sarah Boe Wirenfeldt, Martin Fumagalli, Marta Mannella, Francesca Carolina Marangon, Davide Lambertsen, Kate Lykke Raffaele, Stefano Lecca, Davide Abbracchio, Maria Pia Madsen, Kirsten Corradini, Silvia |
| AuthorAffiliation | 3 Department of Clinical Research, Brain Research – Inter Disciplinary Guided Excellence (BRIDGE) University of Southern Denmark Odense Denmark 8 Department of Neurology Odense University Hospital Odense Denmark 2 Department of Neurobiology Research, Institute of Molecular Medicine University of Southern Denmark Odense Denmark 5 Department of Pathology South Denmark University Hospital Odense Denmark 7 Department of Cardiovascular and Renal Research, Institute of Molecular Medicine University of Southern Denmark Odense Denmark 4 Odense Patient data Explorative Network (OPEN), Department of Clinical Research, Odense University Hospital University of Southern Denmark Odense Denmark 6 Department of Pharmaceutical Sciences Università degli Studi di Milano Milan Italy 1 Department of Pharmacological and Biomolecular Sciences ‘Rodolfo Paoletti’ Università degli Studi di Milano Milan Italy |
| AuthorAffiliation_xml | – name: 2 Department of Neurobiology Research, Institute of Molecular Medicine University of Southern Denmark Odense Denmark – name: 3 Department of Clinical Research, Brain Research – Inter Disciplinary Guided Excellence (BRIDGE) University of Southern Denmark Odense Denmark – name: 5 Department of Pathology South Denmark University Hospital Odense Denmark – name: 1 Department of Pharmacological and Biomolecular Sciences ‘Rodolfo Paoletti’ Università degli Studi di Milano Milan Italy – name: 7 Department of Cardiovascular and Renal Research, Institute of Molecular Medicine University of Southern Denmark Odense Denmark – name: 4 Odense Patient data Explorative Network (OPEN), Department of Clinical Research, Odense University Hospital University of Southern Denmark Odense Denmark – name: 6 Department of Pharmaceutical Sciences Università degli Studi di Milano Milan Italy – name: 8 Department of Neurology Odense University Hospital Odense Denmark |
| Author_xml | – sequence: 1 givenname: Stefano orcidid: 0000-0002-2734-5418 surname: Raffaele fullname: Raffaele, Stefano organization: Università degli Studi di Milano – sequence: 2 givenname: Bettina Hjelm orcidid: 0000-0003-3302-2022 surname: Clausen fullname: Clausen, Bettina Hjelm organization: University of Southern Denmark – sequence: 3 givenname: Francesca Carolina orcidid: 0009-0004-7476-8212 surname: Mannella fullname: Mannella, Francesca Carolina organization: Università degli Studi di Milano – sequence: 4 givenname: Martin orcidid: 0000-0001-9047-5787 surname: Wirenfeldt fullname: Wirenfeldt, Martin organization: South Denmark University Hospital – sequence: 5 givenname: Davide orcidid: 0000-0003-2606-8110 surname: Marangon fullname: Marangon, Davide organization: Università degli Studi di Milano – sequence: 6 givenname: Sarah Boe surname: Tidgen fullname: Tidgen, Sarah Boe organization: University of Southern Denmark – sequence: 7 givenname: Silvia surname: Corradini fullname: Corradini, Silvia organization: University of Southern Denmark – sequence: 8 givenname: Kirsten surname: Madsen fullname: Madsen, Kirsten organization: University of Southern Denmark – sequence: 9 givenname: Davide orcidid: 0000-0002-3258-363X surname: Lecca fullname: Lecca, Davide organization: Università degli Studi di Milano – sequence: 10 givenname: Maria Pia orcidid: 0000-0002-7833-3388 surname: Abbracchio fullname: Abbracchio, Maria Pia organization: Università degli Studi di Milano – sequence: 11 givenname: Kate Lykke orcidid: 0000-0001-9276-4902 surname: Lambertsen fullname: Lambertsen, Kate Lykke email: klambertsen@health.sdu.dk organization: Odense University Hospital – sequence: 12 givenname: Marta orcidid: 0000-0002-0158-842X surname: Fumagalli fullname: Fumagalli, Marta email: marta.fumagalli@unimi.it organization: Università degli Studi di Milano |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39703181$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10kFvFCEUB3Biauy2evALGBIvepgWhplhOJlmo61JExtTzwSYNzs0DIww07o3z578jH4SWbc2auKJkPfjzyO8I3TggweEnlNyQgkpTyc1DycNa-kjtKJENIVoRXOAVrlWFqyi_BAdpXRDCBGirp-gQyY4YbSlK_RtPaiozAzRJjXb4HHo8fnVR8p_fP0OX6YIKVm_wcHZTejAdzGY7Qw4F8wSU4gJW4-HZVQe22QGBaM12EHKUQkr32ETYgS3z76z84Aj5PvsLeCNs8rlbZqyhfQUPe6VS_Dsfj1Gn969vV5fFJcfzt-vzy4LU5GKFqY2ptad6ZXSAkSpGRedKhWrgeuStUK3lTZVZ8CQptac6Er3TLCm7FStMj9Gb_a506JHyM7PUTk5RTuquJVBWfl3xdtBbsKtpJRTXgmWE17dJ8TweYE0yzG_HZxTHsKSJKMVr9qK8zrTl__Qm7BEn9-XVc3KmvOGZPXiz5Yeevn9Txm83gMTQ0oR-gdCidzNgNzNgNzNQLane3tnHWz_D-XV2fXFrxM_AUfUuQI |
| Cites_doi | 10.1093/nar/gkac1000 10.1002/glia.23305 10.1016/j.bbi.2023.12.025 10.1002/dneu.22541 10.1007/s12035-021-02401-1 10.1038/cddis.2017.256 10.1038/nn.2410 10.1093/brain/awae029 10.1371/journal.pbio.1001743 10.1002/glia.22929 10.1016/j.neulet.2023.137405 10.1016/j.tins.2020.05.006 10.1016/j.neulet.2019.03.005 10.1371/journal.pone.0003579 10.1038/sj.emboj.7601341 10.1002/glia.24426 10.1161/STROKEAHA.122.039138 10.1038/nature04302 10.1007/s12975-023-01201-0 10.1016/j.nbd.2018.07.023 10.1038/s41467-019-12059-y 10.1161/CIR.0000000000001123 10.1074/jbc.M110.162867 10.3390/ijms22094574 10.1126/scitranslmed.aam7816 10.1093/nar/gkac947 10.1038/75556 10.2174/1570159X19666210610093658 10.1007/s10571-020-01014-x 10.1093/nar/gkz240 10.1093/database/bau012 10.1111/bpa.12583 10.1093/database/baz046 10.1016/j.nbd.2020.105008 10.1016/j.bbadis.2018.09.012 10.1016/j.neuropharm.2015.10.005 10.1038/ncomms9518 10.3390/ijms21072395 10.1016/j.ymthe.2020.12.009 10.1007/978-1-4939-9658-2_2 10.1111/cns.13497 10.1002/glia.22896 10.1038/s41593-023-01553-8 10.1093/nar/gkad960 10.1016/j.nbd.2015.05.003 10.1002/glia.23807 10.3390/cells13121024 10.1016/j.neuroscience.2011.11.066 10.1126/science.aaf6463 10.1523/JNEUROSCI.0103-19.2019 10.3389/fncel.2022.950819 10.1038/s41582-019-0184-2 10.1007/s11302-013-9366-3 10.1007/s00281-022-00969-x 10.1093/nar/gkw377 10.1002/glia.21237 10.1016/j.phrs.2019.02.025 10.1186/s40478-020-00957-y 10.1111/bph.16408 |
| ContentType | Journal Article |
| Copyright | 2024 The Author(s). published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 The Author(s). published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. – notice: 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. – notice: 2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7QR 7T5 7TK 7TM 7TO 8FD FR3 H94 K9. P64 RC3 7X8 5PM |
| DOI | 10.1002/path.6381 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef Genetics Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | GPR17 and reactive glia in human ischaemic stroke |
| EISSN | 1096-9896 |
| EndPage | 243 |
| ExternalDocumentID | PMC11717493 39703181 10_1002_path_6381 PATH6381 |
| Genre | researchArticle Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Brain Research Inter Disciplinary Guided Excellence (BRIDGE) – fundername: Fondazione Umberto Veronesi – fundername: Danmarks Frie Forskningsfond funderid: 0134‐00084B – fundername: Danmarks Frie Forskningsfond grantid: 0134-00084B |
| GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 123 1KJ 1L6 1OB 1OC 1ZS 24P 29L 31~ 33P 3O- 3SF 3UE 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AHMBA AI. AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA GSXLS H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M J5H JPC KBYEO KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M68 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MVM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OHT OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWI RX1 SAMSI SUPJJ SV3 TEORI UB1 V2E VH1 W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 XPP XV2 YQI YQJ ZGI ZXP ZZTAW ~IA ~KM ~WT AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION CGR CUY CVF ECM EIF NPM 7QP 7QR 7T5 7TK 7TM 7TO 8FD AAMMB AEFGJ AGXDD AIDQK AIDYY FR3 H94 K9. P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c4041-c5cc5bdcfaab9e92b379da2a35e7b2389b84bc4dcec065b70b4bf39362da5a2b3 |
| IEDL.DBID | DR2 |
| ISSN | 0022-3417 1096-9896 |
| IngestDate | Thu Aug 21 18:28:42 EDT 2025 Fri Jul 11 03:40:57 EDT 2025 Sun Jul 27 07:11:30 EDT 2025 Fri Jun 27 02:10:53 EDT 2025 Tue Jul 01 05:17:04 EDT 2025 Wed Jan 22 17:11:08 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | oligodendrocyte precursor cells ischaemic stroke glial cell interactions neuroinflammation oligodendrocytes GPR17 receptor astrocytes microglia post‐mortem brain tissue remyelination |
| Language | English |
| License | Attribution 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4041-c5cc5bdcfaab9e92b379da2a35e7b2389b84bc4dcec065b70b4bf39362da5a2b3 |
| Notes | These authors contributed equally to this work. No conflicts of interest were declared. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-7833-3388 0000-0002-2734-5418 0000-0003-3302-2022 0000-0003-2606-8110 0000-0001-9276-4902 0000-0001-9047-5787 0009-0004-7476-8212 0000-0002-3258-363X 0000-0002-0158-842X |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpath.6381 |
| PMID | 39703181 |
| PQID | 3153257760 |
| PQPubID | 1006392 |
| PageCount | 18 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11717493 proquest_miscellaneous_3147484775 proquest_journals_3153257760 pubmed_primary_39703181 crossref_primary_10_1002_path_6381 wiley_primary_10_1002_path_6381_PATH6381 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | February 2025 |
| PublicationDateYYYYMMDD | 2025-02-01 |
| PublicationDate_xml | – month: 02 year: 2025 text: February 2025 |
| PublicationDecade | 2020 |
| PublicationPlace | Chichester, UK |
| PublicationPlace_xml | – name: Chichester, UK – name: England – name: Bognor Regis |
| PublicationTitle | The Journal of pathology |
| PublicationTitleAlternate | J Pathol |
| PublicationYear | 2025 |
| Publisher | John Wiley & Sons, Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: John Wiley & Sons, Ltd – name: Wiley Subscription Services, Inc |
| References | 2017; 8 2019; 2019 2021; 20 2021; 22 2019; 10 2021; 29 2019; 15 2019; 126 2023; 147 2011; 59 2008; 3 2016; 104 2024; 147 2012; 202 2017; 9 2024; 181 2013; 9 2009; 12 2020; 8 2013; 11 2024; 116 2006; 25 2020; 1866 2016; 85 2016; 352 2023; 812 2020; 43 2018; 78 2024; 27 2023; 71 2011; 286 2016; 44 2023; 51 2018; 28 2015; 6 2000; 25 2020; 143 2009 2019; 39 2005; 438 2024; 52 2022; 42 2014; 2014 2019; 703 2024; 13 2019; 2034 2018; 66 2019; 142 2021; 58 2023; 45 2023 2015; 63 2019; 47 2016; 64 2020; 26 2020; 68 2022; 53 2020; 21 2022; 16 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_50_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_54_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_60_1 e_1_2_9_2_1 Portney LG (e_1_2_9_38_1) 2009 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_15_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_59_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_61_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 e_1_2_9_3_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1 |
| References_xml | – year: 2009 – volume: 147 start-page: e93 year: 2023 end-page: e621 article-title: Heart disease and stroke statistics‐2023 update: a report from the American Heart Association publication-title: Circulation – volume: 126 start-page: 5 year: 2019 end-page: 12 article-title: Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke publication-title: Neurobiol Dis – volume: 13 start-page: 1024 year: 2024 article-title: Oligodendrocyte progenitors in glial scar: a bet on remyelination publication-title: Cells – volume: 16 year: 2022 article-title: Dynamics of microglia activation in the ischemic brain: implications for myelin repair and functional recovery publication-title: Front Cell Neurosci – volume: 9 year: 2017 article-title: BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions publication-title: Sci Transl Med – volume: 2014 year: 2014 article-title: COMPARTMENTS: unification and visualization of protein subcellular localization evidence publication-title: Database (Oxford) – volume: 53 start-page: 1500 year: 2022 end-page: 1509 article-title: Sex differences in poststroke inflammation: a focus on microglia across the lifespan publication-title: Stroke – volume: 26 start-page: 1219 year: 2020 end-page: 1229 article-title: Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy publication-title: CNS Neurosci Ther – volume: 58 start-page: 4107 year: 2021 end-page: 4121 article-title: Integrative multi‐omics analysis to characterize human brain ischemia publication-title: Mol Neurobiol – volume: 104 start-page: 82 year: 2016 end-page: 93 article-title: CNS remyelination as a novel reparative approach to neurodegenerative diseases: the roles of purinergic signaling and the P2Y‐like receptor GPR17 publication-title: Neuropharmacology – volume: 42 start-page: 1225 year: 2022 end-page: 1240 article-title: Prenatal stress impairs spinal cord oligodendrocyte maturation via BDNF signaling in the experimental autoimmune encephalomyelitis model of multiple sclerosis publication-title: Cell Mol Neurobiol – volume: 51 start-page: D870 year: 2023 end-page: D876 article-title: CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA‐seq data publication-title: Nucleic Acids Res – volume: 59 start-page: 1958 year: 2011 end-page: 1973 article-title: The GPR17 receptor in NG2 expressing cells: focus on cell maturation and participation in acute trauma and chronic damage publication-title: Glia – volume: 63 start-page: 2327 year: 2015 end-page: 2339 article-title: The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein‐coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization publication-title: Glia – volume: 51 start-page: D638 year: 2023 end-page: D646 article-title: The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest publication-title: Nucleic Acids Res – volume: 703 start-page: 139 year: 2019 end-page: 144 article-title: Neuronal activity‐dependent myelin repair after stroke publication-title: Neurosci Lett – volume: 2034 start-page: 13 year: 2019 end-page: 26 article-title: Morphology of microglia across contexts of health and disease publication-title: Methods Mol Biol – volume: 52 start-page: D679 year: 2024 end-page: D689 article-title: WikiPathways 2024: next generation pathway database publication-title: Nucleic Acids Res – volume: 9 start-page: 451 year: 2013 end-page: 462 article-title: Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury publication-title: Purinergic Signal – volume: 64 start-page: 287 year: 2016 end-page: 299 article-title: GPR17 expressing NG2‐glia: oligodendrocyte progenitors serving as a reserve pool after injury publication-title: Glia – volume: 20 start-page: 751 year: 2021 end-page: 765 article-title: Pathways involved in remyelination after cerebral ischemia publication-title: Curr Neuropharmacol – volume: 812 year: 2023 article-title: Evaluation of BCAS1‐positive immature oligodendrocytes after cerebral ischemic stroke and SVD publication-title: Neurosci Lett – volume: 8 year: 2017 article-title: The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke publication-title: Cell Death Dis – volume: 39 start-page: 9343 year: 2019 end-page: 9359 article-title: White matter stroke induces a unique oligo‐astrocyte niche that inhibits recovery publication-title: J Neurosci – year: 2023 article-title: Inhibition of GPR17/ID2 Axis improve remyelination and cognitive recovery after SAH by mediating OPC differentiation in rat model publication-title: Transl Stroke Res – volume: 2019 year: 2019 article-title: PanglaoDB: a web server for exploration of mouse and human single‐cell RNA sequencing data publication-title: Database (Oxford) – volume: 25 start-page: 4615 year: 2006 end-page: 4627 article-title: The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor publication-title: EMBO J – volume: 181 start-page: 3303 year: 2024 end-page: 3326 article-title: Montelukast improves disease outcome in SOD1G93A female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity publication-title: Br J Pharmacol – volume: 29 start-page: 1439 year: 2021 end-page: 1458 article-title: Microglial vesicles improve post‐stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis publication-title: Mol Ther – volume: 3 year: 2008 article-title: The recently identified P2Y‐like receptor GPR17 is a sensor of brain damage and a new target for brain repair publication-title: PLoS One – volume: 10 start-page: 4125 year: 2019 article-title: Oligodendrocytes express synaptic proteins that modulate myelin sheath formation publication-title: Nat Commun – volume: 27 start-page: 219 year: 2024 end-page: 231 article-title: Synaptic input and Ca activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation publication-title: Nat Neurosci – volume: 43 start-page: 596 year: 2020 end-page: 607 article-title: The role of astrocytes in remyelination publication-title: Trends Neurosci – volume: 6 start-page: 8518 year: 2015 article-title: Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors publication-title: Nat Commun – volume: 147 start-page: 1294 year: 2024 end-page: 1311 article-title: Prolonged myelin deficits contribute to neuron loss and functional impairments after ischaemic stroke publication-title: Brain – volume: 45 start-page: 295 year: 2023 end-page: 313 article-title: Sex differences in the inflammatory response to stroke publication-title: Semin Immunopathol – volume: 15 start-page: 447 year: 2019 end-page: 458 article-title: The pro‐remyelination properties of microglia in the central nervous system publication-title: Nat Rev Neurol – volume: 143 year: 2020 article-title: Glia: victims or villains of the aging brain? publication-title: Neurobiol Dis – volume: 438 start-page: 1162 year: 2005 end-page: 1166 article-title: NMDA receptors are expressed in oligodendrocytes and activated in ischaemia publication-title: Nature – volume: 25 start-page: 25 year: 2000 end-page: 29 article-title: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium publication-title: Nat Genet – volume: 8 start-page: 81 year: 2020 article-title: Characterization of the TNF and IL‐1 systems in human brain and blood after ischemic stroke publication-title: Acta Neuropathol Commun – volume: 71 start-page: 2499 year: 2023 end-page: 2510 article-title: The committed oligodendrocyte precursor cell, a newly‐defined intermediate progenitor cell type in oligodendroglial lineage publication-title: Glia – volume: 22 start-page: 4574 year: 2021 article-title: The distribution of GPR17‐expressing cells correlates with white matter inflammation status in brain tissues of multiple sclerosis patients publication-title: Int J Mol Sci – volume: 28 start-page: 791 year: 2018 end-page: 805 article-title: Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts publication-title: Brain Pathol – volume: 202 start-page: 42 year: 2012 end-page: 57 article-title: The new P2Y‐like receptor G protein‐coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats publication-title: Neuroscience – volume: 11 year: 2013 article-title: Neuregulin and BDNF induce a switch to NMDA receptor‐dependent myelination by oligodendrocytes publication-title: PLoS Biol – volume: 21 start-page: 2395 year: 2020 article-title: Abnormal upregulation of GPR17 receptor contributes to oligodendrocyte dysfunction in SOD1 G93A mice publication-title: Int J Mol Sci – volume: 47 start-page: W234 year: 2019 end-page: W241 article-title: NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta‐analysis publication-title: Nucleic Acids Res – volume: 68 start-page: 1957 year: 2020 end-page: 1967 article-title: Regulation and signaling of the GPR17 receptor in oligodendroglial cells publication-title: Glia – volume: 12 start-page: 1398 year: 2009 end-page: 1406 article-title: The oligodendrocyte‐specific G protein‐coupled receptor GPR17 is a cell‐intrinsic timer of myelination publication-title: Nat Neurosci – volume: 78 start-page: 123 year: 2018 end-page: 135 article-title: Bad wrap: myelin and myelin plasticity in health and disease publication-title: Dev Neurobiol – volume: 44 start-page: W90 year: 2016 end-page: W97 article-title: Enrichr: a comprehensive gene set enrichment analysis web server 2016 update publication-title: Nucleic Acids Res – volume: 85 start-page: 234 year: 2016 end-page: 244 article-title: Reactive astrocytes and therapeutic potential in focal ischemic stroke publication-title: Neurobiol Dis – volume: 352 start-page: 1326 year: 2016 end-page: 1329 article-title: Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system publication-title: Science – volume: 66 start-page: 1118 year: 2018 end-page: 1130 article-title: Differential local tissue permissiveness influences the final fate of GPR17‐expressing oligodendrocyte precursors in two distinct models of demyelination publication-title: Glia – volume: 1866 year: 2020 article-title: Current advances in ischemic stroke research and therapies publication-title: Biochim Biophys Acta Mol Basis Dis – volume: 116 start-page: 269 year: 2024 end-page: 285 article-title: Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex‐specific fashion publication-title: Brain Behav Immun – volume: 142 start-page: 223 year: 2019 end-page: 236 article-title: Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti‐asthmatic drug publication-title: Pharmacol Res – volume: 286 start-page: 10593 year: 2011 end-page: 10604 article-title: Phenotypic changes, signaling pathway, and functional correlates of GPR17‐expressing neural precursor cells during oligodendrocyte differentiation publication-title: J Biol Chem – ident: e_1_2_9_37_1 doi: 10.1093/nar/gkac1000 – ident: e_1_2_9_13_1 doi: 10.1002/glia.23305 – ident: e_1_2_9_27_1 doi: 10.1016/j.bbi.2023.12.025 – ident: e_1_2_9_47_1 doi: 10.1002/dneu.22541 – ident: e_1_2_9_29_1 doi: 10.1007/s12035-021-02401-1 – ident: e_1_2_9_16_1 doi: 10.1038/cddis.2017.256 – ident: e_1_2_9_9_1 doi: 10.1038/nn.2410 – ident: e_1_2_9_5_1 doi: 10.1093/brain/awae029 – ident: e_1_2_9_60_1 doi: 10.1371/journal.pbio.1001743 – ident: e_1_2_9_17_1 doi: 10.1002/glia.22929 – ident: e_1_2_9_48_1 doi: 10.1016/j.neulet.2023.137405 – ident: e_1_2_9_23_1 doi: 10.1016/j.tins.2020.05.006 – ident: e_1_2_9_61_1 doi: 10.1016/j.neulet.2019.03.005 – ident: e_1_2_9_8_1 doi: 10.1371/journal.pone.0003579 – ident: e_1_2_9_51_1 doi: 10.1038/sj.emboj.7601341 – ident: e_1_2_9_12_1 doi: 10.1002/glia.24426 – volume-title: Foundations of Clinical Research: Applications to Practice year: 2009 ident: e_1_2_9_38_1 – ident: e_1_2_9_58_1 doi: 10.1161/STROKEAHA.122.039138 – ident: e_1_2_9_43_1 doi: 10.1038/nature04302 – ident: e_1_2_9_53_1 doi: 10.1007/s12975-023-01201-0 – ident: e_1_2_9_4_1 doi: 10.1016/j.nbd.2018.07.023 – ident: e_1_2_9_46_1 doi: 10.1038/s41467-019-12059-y – ident: e_1_2_9_2_1 doi: 10.1161/CIR.0000000000001123 – ident: e_1_2_9_7_1 doi: 10.1074/jbc.M110.162867 – ident: e_1_2_9_26_1 doi: 10.3390/ijms22094574 – ident: e_1_2_9_39_1 doi: 10.1126/scitranslmed.aam7816 – ident: e_1_2_9_31_1 doi: 10.1093/nar/gkac947 – ident: e_1_2_9_33_1 doi: 10.1038/75556 – ident: e_1_2_9_24_1 doi: 10.2174/1570159X19666210610093658 – ident: e_1_2_9_15_1 doi: 10.1007/s10571-020-01014-x – ident: e_1_2_9_36_1 doi: 10.1093/nar/gkz240 – ident: e_1_2_9_34_1 doi: 10.1093/database/bau012 – ident: e_1_2_9_57_1 doi: 10.1111/bpa.12583 – ident: e_1_2_9_32_1 doi: 10.1093/database/baz046 – ident: e_1_2_9_42_1 doi: 10.1016/j.nbd.2020.105008 – ident: e_1_2_9_3_1 doi: 10.1016/j.bbadis.2018.09.012 – ident: e_1_2_9_54_1 doi: 10.1016/j.neuropharm.2015.10.005 – ident: e_1_2_9_44_1 doi: 10.1038/ncomms9518 – ident: e_1_2_9_14_1 doi: 10.3390/ijms21072395 – ident: e_1_2_9_18_1 doi: 10.1016/j.ymthe.2020.12.009 – ident: e_1_2_9_40_1 doi: 10.1007/978-1-4939-9658-2_2 – ident: e_1_2_9_49_1 doi: 10.1111/cns.13497 – ident: e_1_2_9_10_1 doi: 10.1002/glia.22896 – ident: e_1_2_9_45_1 doi: 10.1038/s41593-023-01553-8 – ident: e_1_2_9_35_1 doi: 10.1093/nar/gkad960 – ident: e_1_2_9_55_1 doi: 10.1016/j.nbd.2015.05.003 – ident: e_1_2_9_19_1 doi: 10.1002/glia.23807 – ident: e_1_2_9_56_1 doi: 10.3390/cells13121024 – ident: e_1_2_9_52_1 doi: 10.1016/j.neuroscience.2011.11.066 – ident: e_1_2_9_11_1 doi: 10.1126/science.aaf6463 – ident: e_1_2_9_41_1 doi: 10.1523/JNEUROSCI.0103-19.2019 – ident: e_1_2_9_22_1 doi: 10.3389/fncel.2022.950819 – ident: e_1_2_9_21_1 doi: 10.1038/s41582-019-0184-2 – ident: e_1_2_9_50_1 doi: 10.1007/s11302-013-9366-3 – ident: e_1_2_9_59_1 doi: 10.1007/s00281-022-00969-x – ident: e_1_2_9_30_1 doi: 10.1093/nar/gkw377 – ident: e_1_2_9_6_1 doi: 10.1002/glia.21237 – ident: e_1_2_9_20_1 doi: 10.1016/j.phrs.2019.02.025 – ident: e_1_2_9_25_1 doi: 10.1186/s40478-020-00957-y – ident: e_1_2_9_28_1 doi: 10.1111/bph.16408 |
| SSID | ssj0009955 |
| Score | 2.4660182 |
| Snippet | White matter damage and subsequent demyelination significantly contribute to long‐term functional impairment after ischaemic stroke. Identifying novel... White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel... |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 226 |
| SubjectTerms | Aged Aged, 80 and over Astrocytes Brain injury Brain Ischemia - metabolism Brain Ischemia - pathology Breast cancer Breast carcinoma Cell Differentiation Cell surface receptors Demyelination Female glial cell interactions Glial cells Glial stem cells GPR17 receptor Humans Immunohistochemistry ischaemic stroke Ischemia Ischemic Stroke - metabolism Ischemic Stroke - pathology Macrophages Male Microglia Microglia - metabolism Microglia - pathology Middle Aged Myelin Myelination Neuroglia - metabolism Neuroglia - pathology neuroinflammation oligodendrocyte precursor cells Oligodendrocyte Precursor Cells - metabolism Oligodendrocyte Precursor Cells - pathology Oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - pathology Original Phagocytes Phenotypes post‐mortem brain tissue Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism remyelination Stroke Substantia alba Transcriptomics |
| Title | Characterisation of GPR17‐expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpath.6381 https://www.ncbi.nlm.nih.gov/pubmed/39703181 https://www.proquest.com/docview/3153257760 https://www.proquest.com/docview/3147484775 https://pubmed.ncbi.nlm.nih.gov/PMC11717493 |
| Volume | 265 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VHhAX3o-UUhnEgUu2iR-bWpyqirJCKlpVrdQDUuRX2oglWzW7EnDizInfyC9hxtnNslRIiFsiTxLHnrG_scffALz0Q3Q7vBKpCUam0lqfmrzKUld5W2gtM8HpvPPR--HoVL47U2cb8Hp5Fqbjh-gX3Mgy4nhNBm5su7siDaWMvQPUHnJ9KFaLANHxijpKa6V6pnCZF0tWoYzv9k-uz0XXAOb1OMnf8WucgA7vwIdl1bu4k4-D-cwO3Nc_WB3_89_uwu0FMGX7nSbdg43Q3IebR4ut9wfw_WBF7Rx7k00r9nZ8nBc_v_0In7t42uacTSc1urqBeBDcl1lgWODmiOqvWlY3LKYEZHVLsfqfascmgVbrWmYazxwlCulC8xgtDzPEs3E0ZucTtBK8jeG8oX0Ip4dvTg5G6SKRQ-pkJvPUKeeU9a4yxuqguRWF9oYboUJhETNouyetk9jODhGRLTIrbSU0zq3eKIPij2CzmTbhCTAugrG8QlSmhFSGvLVhJrzNeSBn1ifwYtml5WXH11F2zMy8pFYtqVUT2F52drkw2bYU-EYcv4phlsDzvhiNjXZQTBOmc5KRxL1aFCqBx51u9F9BYEcDJL58b01regEi8l4vaeqLSOid5-hUSy0SeBW14u81L8f7JyO62Pp30adwi1PS4hhqvg2bs6t5eIZIamZ34AaX451oOL8AxeUikg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRQIuvB-BAgZx4JJtEtubWuJSFcoC3aqqtlIvKPIrZdVtFjW7EnDizInfyC9hxtlkWSokxC2RJ4ljz9jf2ONvAJ67ProdTvJYey1iYYyLdVomsS2dyZUSCc_ovPNwvz84Eu-O5fEavGzPwjT8EN2CG1lGGK_JwGlBenPJGkope3uoPuj7XKKM3sSc_-pwSR6llJQdV7hI85ZXKMk2u0dXZ6MLEPNipOTvCDZMQbvX4UNb-Sby5LQ3n5me_foHr-P__t0NuLbApmy7UaabsOarW3B5uNh9vw3fd5bszqFD2bRkbw4O0_zntx_-cxNSW52w6WSM3q4nKgT7ZeYZFtg5Avvzmo0rFrICsnFN4fpnY8smnhbsaqYrxyzlCmmi8xitEDOEtGFAZicTNBS8DRG9vr4DR7uvRzuDeJHLIbYiEWlspbXSOFtqbZRXmeG5cjrTXPrcIGxQZksYK7ChLYIikydGmJIrnF6dlhrF78J6Na38fWAZ99pkJQIzyYXU5LD1E-5MmnnyZ10Ez9o-LT41lB1FQ86cFdSqBbVqBBttbxcLq60Ljm_EISzvJxE87YrR3mgTRVd-OicZQfSreS4juNcoR_cVxHY0RuLLt1bUphMgLu_Vkmr8MXB6pyn61ULxCF4Etfh7zYuD7dGALh78u-gTuDIYDfeKvbf77x_C1YxyGIfI8w1Yn53P_SMEVjPzONjPL-HOJdc |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB5VRaq4ICivQGkN4sAlNPFj3YhTVViWR6sVaqXeIr9SIi3ZqtmV4MaZE7-RX8KMs5vtqkLilsiThzwz9jf2-BuAl36AYYdXIjXByFRa61OTV1nqKm91UchMcDrvfHwyGJ3Jj-fqfAPeLM_CdPwQ_YIbeUYcr8nBL321vyINpYq9r9F6MPS5RZt9lM_F5XjFuFso1VOFy1wvaYUyvt8_uj4Z3UCYNxMlrwPYOAMN78KdBXRkh52u78FGaLZh63ixOX4ffh2tyJdjf7Npxd6Pv-T6z8_f4XuX8dpcsOmkxmA0EFOB-zELDBvcHHH3VcvqhsWifaxuKZv-W-3YJNB6WstM45mjUh5d8hyjBVyGiDOOl-xignaMtzHhNrQP4Gz47vRolC5KLaROZjJPnXJOWe8qY2wRCm6FLrzhRqigLc7qhT2Q1knsCIeYxerMSluJAmc_b5RB8Yew2Uyb8BgYF8FYXiFuUkIqQ_HUIBPe5jxQuOkTeLHs8_KyY9QoO-5kXpJiSlJMAjtLbZQLp2pLgW_EEUYPsgSe983oDrTHYZownZOMJHZUrVUCjzrl9V9B6EVDGL78YE2tvQBRba-3NPXXSLmd5xj2ykIk8CpawL__vBwfno7o4sn_i-7B1vjtsPz84eTTU7jNqcJwzAvfgc3Z1Tw8Q9gzs7vRvP8CYXgEFg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characterisation+of+GPR17%E2%80%90expressing+oligodendrocyte+precursors+in+human+ischaemic+lesions+and+correlation+with+reactive+glial+responses&rft.jtitle=The+Journal+of+pathology&rft.au=Raffaele%2C+Stefano&rft.au=Clausen%2C+Bettina+Hjelm&rft.au=Mannella%2C+Francesca+Carolina&rft.au=Wirenfeldt%2C+Martin&rft.date=2025-02-01&rft.pub=John+Wiley+%26+Sons%2C+Ltd&rft.issn=0022-3417&rft.eissn=1096-9896&rft.volume=265&rft.issue=2&rft.spage=226&rft.epage=243&rft_id=info:doi/10.1002%2Fpath.6381&rft.externalDBID=10.1002%252Fpath.6381&rft.externalDocID=PATH6381 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3417&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3417&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3417&client=summon |