Unilateral GPi-DBS Improves Ipsilateral and Axial Motor Symptoms in Parkinson's Disease as Evidenced by a Brain Perfusion Single Photon Emission Computed Tomography Study

• Published in: Frontiers in human neuroscience Vol. 16; p. 888701
• Main Authors: Hayashi, Yuka, Mishima, Takayasu, Fujioka, Shinsuke, Morishita, Takashi, Inoue, Tooru, Nagamachi, Shigeki, Tsuboi, Yoshio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.05.2022; Frontiers Media S.A
• Subjects: Blood flow; Cerebral blood flow; Cerebral cortex; Cognitive ability; Computed tomography; Cortex (premotor); deep brain stimuation; Deep brain stimulation; Drug dosages; Dyskinesia; Electrical stimuli; Frontal lobe; globus pallidum internus (Gpi); Globus pallidus; ipsilateral; Levodopa; Movement disorders; Neurodegenerative diseases; Neuroscience; Parkinson's disease; Parkinson’s disease (PD); Patients; Perfusion; Single photon emission computed tomography; Solitary tract nucleus; Subthalamic nucleus; subthalamic nucleus (STN); Tomography; unilateral; Japan; subthalamic nucleus (STN); axial; deep brain stimuation; globus pallidum internus (Gpi); single photon emission computed tomography (SPECT); Parkinson’s disease (PD); unilateral; ipsilateral

Deep brain stimulation (DBS) is an effective treatment for advanced Parkinson's disease (PD) with the targeting bilateral subthalamic nucleus or globus pallidus internus (STN or GPi-DBS). So far, detailed studies on the efficacy of unilateral STN-DBS for motor symptoms have been reported, but f...