Steroid hormone 20‐hydroxyecdysone disturbs fat body lipid metabolism and negatively regulates gluconeogenesis in Hyphantria cunea larvae

• Published in: Insect science Vol. 30; no. 3; pp. 771 - 788
• Main Authors: Zhang, Sheng‐Yu, Gao, Han, Askar, Ankarjan, Li, Xing‐Peng, Zhang, Guo‐Cai, Jing, Tian‐Zhong, Zou, Hang, Guan, Hao, Zhao, Yun‐He, Zou, Chuan‐Shan
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.06.2023
• Subjects: 20‐hydroxyecdysone; Animals; body fat; carboxy-lyases; ecdysterone; Ecdysterone - metabolism; Fat body; Fat Body - metabolism; Fat metabolism; Fatty Acids; forestry; Gluconeogenesis; Glucose; Glucose metabolism; glucose-6-phosphatase; Homeostasis; hormonal regulation; Hyphantria cunea; Insects; Larva - genetics; Larvae; Lipid Metabolism; lipidomics; lipidomics analysis; Lipids; Lipolysis; Metabolism; Moths - genetics; Oxidation; pests; Pyruvate carboxylase; Pyruvic acid; Regulatory mechanisms (biology); steroid hormones; Steroids; lipidomics analysis; Hyphantria cunea; gluconeogenesis; fat body; 20-hydroxyecdysone; lipid metabolism

The steroid hormone 20‐hydroxyecdysone (20E) has been described to regulate fat body lipid metabolism in insects, but its accurate regulatory mechanism, especially the crosstalk between 20E‐induced lipid metabolism and gluconeogenesis remains largely unclear. Here, we specially investigated the effe...