Compressive force-induced LincRNA-p21 inhibits mineralization of cementoblasts by impeding autophagy

• Published in: The FASEB journal Vol. 36; no. 1; p. e22120
• Main Authors: Liu, Hao, Huang, Yiping, Yang, Yuhui, Han, Yineng, Jia, Lingfei, Li, Weiran
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Animals; Antigens, Differentiation - biosynthesis; Autophagy; Calcification, Physiologic; Compressive Strength; Dental Cementum - metabolism; Down-Regulation; Male; Mice; RNA, Long Noncoding - biosynthesis; cementogenesis; autophagy; biomechanical phenomena; root resorption; RNA, long noncoding

The mineralization capability of cementoblasts is the foundation for repairing orthodontic treatment-induced root resorption. It is essential to investigate the regulatory mechanism of mineralization in cementoblasts under mechanical compression to improve orthodontic therapy. Autophagy has a protec...