Gold()- and rhodium()-catalyzed formal regiodivergent C-H alkynylation of 1-arylpyrazolones

• Published in: Organic & biomolecular chemistry Vol. 16; no. 16; pp. 286 - 2864
• Main Authors: Wang, Xueli, Li, Xingwei, Zhang, Yao, Xia, Lixin
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 2018; Royal Society of Chemistry
• Subjects: Alkynes; Aromatic compounds; Catalysis; Chemistry; Chemistry, Organic; Functional groups; Gold; Iodine; Physical Sciences; Pyrazolones; Reagents; Regioselectivity; Rhodium; Science & Technology; Substrates; CATALYZED DIRECT ALKYNYLATION; DIRECTING GROUPS; FUNCTIONALIZATION; CHELATION-ASSISTANCE; ACTIVATION; MILD CONDITIONS; RH(III); ARENES; DERIVATIVES; INDOLES

Formal regiodivergent C-H alkynylation of 1-aryl-5-pyrazolones has been realized under the catalysis of Rh( iii ) and Au( i ) complexes by using a hypervalent iodine reagent as the alkyne source. Mechanistic studies indicate that the regioselectivity is ascribed to not only the choice of the catalys...