B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity

• Published in: Clinical cancer research Vol. 24; no. 11; pp. 2653 - 2664
• Main Authors: Yonesaka, Kimio, Haratani, Koji, Takamura, Shiki, Sakai, Hitomi, Kato, Ryoji, Takegawa, Naoki, Takahama, Takayuki, Tanaka, Kaoru, Hayashi, Hidetoshi, Takeda, Masayuki, Kato, Sigeki, Maenishi, Osamu, Sakai, Kazuko, Chiba, Yasutaka, Okabe, Takafumi, Kudo, Keita, Hasegawa, Yoshikazu, Kaneda, Hiroyasu, Yamato, Michiko, Hirotani, Kenji, Miyazawa, Masaaki, Nishio, Kazuto, Nakagawa, Kazuhiko
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.06.2018
• Subjects: Aged; Aged, 80 and over; Animals; Anticancer properties; Antineoplastic Agents, Immunological - pharmacology; Antineoplastic Agents, Immunological - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antitumor activity; Apoptosis; B7 antigen; B7 Antigens - metabolism; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - metabolism; Biomarkers, Tumor; Blocking antibodies; Cancer; CD8 antigen; Cell survival; Cytotoxicity; Disease Models, Animal; Drug Resistance, Neoplasm; Effectiveness; Experimental design; Female; Flow cytometry; Humans; Immune checkpoint; Immunity; Immunomodulation; Immunosurveillance; Immunotherapy; Lung cancer; Lymphocytes; Lymphocytes T; Male; Mice; Middle Aged; Molecular chains; Molecular Targeted Therapy; Mutation; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Non-small cell lung carcinoma; PD-1 protein; PD-L1 protein; Prognosis; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - metabolism; Therapy; Treatment Outcome; Tumor cells; Tumor-infiltrating lymphocytes; Tumors; Xenograft Model Antitumor Assays

Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non–small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecule, is expressed in various malignancies. To our knowledge, this stud...