Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 9; pp. 1867 - 1879
• Main Authors: Beli, Eleni, Yan, Yuanqing, Moldovan, Leni, Vieira, Cristiano P., Gao, Ruli, Duan, Yaqian, Prasad, Ram, Bhatwadekar, Ashay, White, Fletcher A., Townsend, Steven D., Chan, Luisa, Ryan, Caitlin N., Morton, Daniel, Moldovan, Emil G., Chu, Fang-I, Oudit, Gavin Y., Derendorf, Hartmut, Adorini, Luciano, Wang, Xiaoxin X., Evans-Molina, Carmella, Mirmira, Raghavendra G., Boulton, Michael E., Yoder, Mervin C., Li, Qiuhong, Levi, Moshe, Busik, Julia V., Grant, Maria B.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2018
• Subjects: Animals; Bacteroidetes - growth & development; Bacteroidetes - immunology; Bacteroidetes - isolation & purification; Bile Acids and Salts - therapeutic use; Cancer; Capillaries; Cell number; Colon - drug effects; Colon - immunology; Colon - metabolism; Colon - pathology; Complications; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - microbiology; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - therapy; Diabetic retinopathy; Diabetic Retinopathy - complications; Diabetic Retinopathy - immunology; Diabetic Retinopathy - pathology; Diabetic Retinopathy - prevention & control; Digestive system; Dysbiosis - complications; Dysbiosis - microbiology; Dysbiosis - pathology; Dysbiosis - therapy; Fasting; Feces - microbiology; Feeding; Firmicutes; Firmicutes - growth & development; Firmicutes - immunology; Firmicutes - isolation & purification; Ganglia, Sensory - drug effects; Ganglia, Sensory - immunology; Ganglia, Sensory - metabolism; Ganglia, Sensory - pathology; Ganglion cells; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - immunology; Goblet Cells - drug effects; Goblet Cells - immunology; Goblet Cells - metabolism; Goblet Cells - pathology; Hemoglobin; Intestinal microflora; Intestinal Mucosa - drug effects; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Laboratory testing; Leukocytes - drug effects; Leukocytes - immunology; Leukocytes - pathology; Male; Metabolites; Mice, Inbred DBA; Mice, Mutant Strains; Microbiomes; Microbiota; Microvasculature; Microvessels - drug effects; Microvessels - immunology; Microvessels - metabolism; Microvessels - pathology; mRNA; Mucin; Neuroprotection; Peptidoglycans; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - metabolism; Retina; Retina - drug effects; Retina - immunology; Retina - metabolism; Retina - pathology; Retinal Vessels - drug effects; Retinal Vessels - immunology; Retinal Vessels - metabolism; Retinal Vessels - pathology; Retinopathy; Rodents; Survival Analysis; Tumor necrosis factor-α; Verrucomicrobia - growth & development; Verrucomicrobia - immunology; Verrucomicrobia - isolation & purification

Intermittent fasting (IF) protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is not known. In db/db mice, we examined the impact of long-term IF on diabetic retinopathy (DR). Despite no change in glycated hemoglobin, db/...