Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis

• Published in: Clinical gastroenterology and hepatology Vol. 19; no. 5; pp. 1067 - 1070.e2
• Main Authors: El-Matary, Wael, Guthery, Stephen L., Amir, Achiya Z., DiGuglielmo, Matthew, Draijer, Laura G., Furuya, Katryn N., Gupta, Nitika, Hochberg, Jessica T., Horslen, Simon, Kerkar, Nanda, Koot, Bart G.P., Laborda, Trevor J., Loomes, Kathleen M., Mack, Cara, Martinez, Mercedes, Miethke, Alexander, Miloh, Tamir, Mogul, Douglas, Mohammed, Saeed, Moroz, Stacy, Ovchinsky, Nadia, Perito, Emily R., Rao, Girish, Ricciuto, Amanda, Sathya, Pushpa, Schwarz, Kathleen B., Shah, Uzma, Singh, Ruchi, Soufi, Nisreen, Valentino, Pamela L., Zizzo, Andréanne, Deneau, Mark R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: Child; Cholangitis, Sclerosing - complications; Cholangitis, Sclerosing - epidemiology; Colitis, Ulcerative - complications; Colorectal Neoplasms - epidemiology; Humans; Inflammatory Bowel Diseases - complications; Risk Factors; IBD-U; PSC; CRC; VEOIBD; IBD; IQR; UC

Inflammatory bowel disease (IBD), especially when associated with primary sclerosing cholangitis (PSC), is a risk factor for developing colorectal cancer (CRC).1–3 We aimed to determine the incidence of CRC in a large cohort of pediatric-onset PSC–ulcerative colitis (UC) patients.