Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis

Inflammatory bowel disease (IBD), especially when associated with primary sclerosing cholangitis (PSC), is a risk factor for developing colorectal cancer (CRC).1–3 We aimed to determine the incidence of CRC in a large cohort of pediatric-onset PSC–ulcerative colitis (UC) patients.

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Published inClinical gastroenterology and hepatology Vol. 19; no. 5; pp. 1067 - 1070.e2
Main Authors El-Matary, Wael, Guthery, Stephen L., Amir, Achiya Z., DiGuglielmo, Matthew, Draijer, Laura G., Furuya, Katryn N., Gupta, Nitika, Hochberg, Jessica T., Horslen, Simon, Kerkar, Nanda, Koot, Bart G.P., Laborda, Trevor J., Loomes, Kathleen M., Mack, Cara, Martinez, Mercedes, Miethke, Alexander, Miloh, Tamir, Mogul, Douglas, Mohammed, Saeed, Moroz, Stacy, Ovchinsky, Nadia, Perito, Emily R., Rao, Girish, Ricciuto, Amanda, Sathya, Pushpa, Schwarz, Kathleen B., Shah, Uzma, Singh, Ruchi, Soufi, Nisreen, Valentino, Pamela L., Zizzo, Andréanne, Deneau, Mark R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2021
Subjects
Child
Cholangitis, Sclerosing - complications
Cholangitis, Sclerosing - epidemiology
Colitis, Ulcerative - complications
Colorectal Neoplasms - epidemiology
Humans
Inflammatory Bowel Diseases - complications
Risk Factors
IBD-U
PSC
CRC
VEOIBD
IBD
IQR
UC
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Summary:Inflammatory bowel disease (IBD), especially when associated with primary sclerosing cholangitis (PSC), is a risk factor for developing colorectal cancer (CRC).1–3 We aimed to determine the incidence of CRC in a large cohort of pediatric-onset PSC–ulcerative colitis (UC) patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
WE: Conceptualization, interpretation of data, and writing original draft.
MD: Conceptualization, investigation, methodology, formal analysis, and reviewing and editing of manuscript
SG, AA, MDG, LGD, KNF, NG, JTH, SH, NK, BGPK, TJL, KML, CM, MM, AM, TM, DM, SM, S Moroz, NO, ERP, GR, AR, PS, KBS, US, RS, NS, PLV, AZ, : Data curation and reviewing and editing of manuscript.
Author contributions
ISSN:1542-3565
1542-7714
DOI:10.1016/j.cgh.2020.04.055