MiR-20b Displays Tumor-Suppressor Functions in Papillary Thyroid Carcinoma by Regulating the MAPK/ERK Signaling Pathway

• Published in: Thyroid (New York, N.Y.) Vol. 26; no. 12; p. 1733
• Main Authors: Hong, Shubin, Yu, Shuang, Li, Jin, Yin, Yali, Liu, Yujie, Zhang, Quan, Guan, Hongyu, Li, Yanbing, Xiao, Haipeng
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Adolescent; Adult; Aged; Apoptosis - genetics; Carcinoma, Papillary - genetics; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Cell Survival - genetics; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System - genetics; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Young Adult; miR-20b; cell viability; invasion; papillary thyroid carcinoma; MAPK/ERK signaling pathway

MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs that play important roles in multiple biological processes. MiR-20b has been reported to be dysregulated in papillary thyroid carcinoma (PTC). However, the functional roles are still largely unknown. This study aimed to investigate the biolog...