Neuroprotective effects of mesenchymal stromal cells in mouse models of Alzheimer’s Disease: The Mediating role of gut microbes and their metabolites via the Microbiome-Gut-Brain axis

• Published in: Brain, behavior, and immunity Vol. 122; pp. 510 - 526
• Main Authors: Xing, Cencan, Zhang, Xiaoshuang, Wang, Donghui, Chen, Hongyu, Gao, Xiaoyu, Sun, Chunbin, Guo, Wenhua, Roshan, Shah, Li, Yingxian, Hang, Zhongci, Cai, Shanglin, Lei, Tong, Bi, Wangyu, Hou, Liangxuan, Li, Luping, Wu, Yawen, Li, Liang, Zeng, Zehua, Du, Hongwu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2024
• Subjects: Alzheimer’s disease; Bile acid metabolism; Gut microbiota; Mesenchymal stromal cells; Microbiome-gut-brain axis; Gut microbiota; APP; FXR; UCMSC; DI; IHC; TUDCA; ChEIs; PXR; WB; GCDCA; DRP1; Aβ; OTU; MSCs; SHED; ANOVA; GPBAR1/TGR5; MMSE; ABX; S1P2R; IF; HPLC; PBS; MWM; AD; DCA; Alzheimer’s disease; p-Tau; ppm; ADSC; Microbiome-gut-brain axis; NOR; TLCA; TCA; BMMSC; PBST; Bile acid metabolism; Mesenchymal stromal cells; HDCA; MGBA

•Three different MSCs have varied therapeutic effects on AD model mice.•The gut microbiota dysbiosis of AD mice could be partially recovered after MSC treatment, antibiotic diminished the therapeutic impacts of MSCs.•MSCs treatment affected the bile acids related microbiota and metabolites.•Both MSC...