The pharmacokinetics of N-[ 14C-formyl]-leurosine in humans

• Published in: European journal of cancer Vol. 17; no. 3; pp. 329 - 335
• Main Authors: Erdélyi-Tóth, V., Csetényi, J., Kanyár, B., Kerpel-Fronius, S., Eckhardt, S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.1981
• Subjects: Antineoplastic Agents, Phytogenic - metabolism; Feces - analysis; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Neoplasms - metabolism; Vinca Alkaloids - blood; Vinca Alkaloids - metabolism; Vinca Alkaloids - urine

N-Formyl-leurosine labeled with 14 C in the formyl group was administered to six patients with malignant disease, and the pharmacokinetic behavior of the drug was determined. Chromatographic studies on plasma showed the presence of unchanged drug and 7 metabolites. No metabolites were found in the u...