ATF4-activated parkin induction contributes to deferasirox-mediated cytoprotection in Parkinson’s disease

• Published in: Toxicological research (Seoul) Vol. 39; no. 2; pp. 191 - 199
• Main Authors: Ham, Sangwoo, Kim, Ji Hun, Kim, Heejeong, Shin, Jeong-Yong, Lee, Yunjong
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.04.2023
• Subjects: Biomedical and Life Sciences; Biomedicine; Original; Original Article; Pharmacology/Toxicology; Deferasirox; ER stress; Dopaminergic cell protection; Parkin induction; Parkinson’s disease; Iron chelator

The E3 ubiquitin ligase parkin plays neuroprotective functions in the brain and the deficits of parkin’s ligase function in Parkinson’s disease (PD) is associated with reduced survival of dopaminergic neurons. Thus, compounds enhancing parkin expression have been developed as potential neuroprotecti...