A protein@metal-organic framework nanocomposite for pH-triggered anticancer drug delivery

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 47; no. 3; pp. 1223 - 1228
• Main Authors: Liang, Zuozhong, Yang, Zhiyuan, Yuan, Haitao, Wang, Chun, Qi, Jing, Liu, Kaiqiang, Cao, Rui, Zheng, Haoquan
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 2018
• Subjects: Biocompatibility; Doxorubicin; Drug delivery systems; Metal-organic frameworks; Nanocomposites; Proteins; Serum albumin

We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated o...