A protein@metal-organic framework nanocomposite for pH-triggered anticancer drug delivery

We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated o...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 47; no. 3; pp. 1223 - 1228
Main Authors Liang, Zuozhong, Yang, Zhiyuan, Yuan, Haitao, Wang, Chun, Qi, Jing, Liu, Kaiqiang, Cao, Rui, Zheng, Haoquan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 2018
Subjects
Biocompatibility
Doxorubicin
Drug delivery systems
Metal-organic frameworks
Nanocomposites
Proteins
Serum albumin
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Abstract We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake. We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell.
AbstractList We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.
We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.
We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake. We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell.
Author Cao, Rui
Zheng, Haoquan
Yuan, Haitao
Wang, Chun
Liu, Kaiqiang
Liang, Zuozhong
Qi, Jing
Yang, Zhiyuan
AuthorAffiliation Ministry of Education
Beijing University of Technology
Shaanxi Normal University
Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering
Xianning Central Hospital
College of Environmental and Energy Engineering
School of Chemistry and Chemical Engineering
The First Affiliated Hospital of Hubei University of Science and Technology
Key Laboratory of Applied Surface and Colloid Chemistry
AuthorAffiliation_xml – sequence: 0
  name: Beijing University of Technology
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  name: The First Affiliated Hospital of Hubei University of Science and Technology
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  name: School of Chemistry and Chemical Engineering
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  name: Ministry of Education
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  name: Xianning Central Hospital
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  name: Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering
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  name: Shaanxi Normal University
– sequence: 0
  name: College of Environmental and Energy Engineering
Author_xml – sequence: 1
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  surname: Liang
  fullname: Liang, Zuozhong
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  givenname: Zhiyuan
  surname: Yang
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  givenname: Haitao
  surname: Yuan
  fullname: Yuan, Haitao
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  fullname: Zheng, Haoquan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30014058$$D View this record in MEDLINE/PubMed
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Snippet We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as...
We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal–organic framework (MOF) as...
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SubjectTerms Biocompatibility
Doxorubicin
Drug delivery systems
Metal-organic frameworks
Nanocomposites
Proteins
Serum albumin
Title A protein@metal-organic framework nanocomposite for pH-triggered anticancer drug delivery
URI https://www.ncbi.nlm.nih.gov/pubmed/30014058
https://www.proquest.com/docview/2079965763
https://www.proquest.com/docview/2071564061
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