Long non-coding RNA HOTAIR in carcinogenesis and metastasis

• Published in: Acta biochimica et biophysica Sinica Vol. 46; no. 1; pp. 1 - 5
• Main Authors: Zhang, Jinsong, Zhang, Peijing, Wang, Li, Piao, Hai-long, Ma, Li
• Format: Journal Article
• Language: English
• Published: China Oxford University Press 01.01.2014
• Series: Editor's choice
• Subjects: Animals; Breast Neoplasms - pathology; Carcinogenesis; Carcinoma, Hepatocellular - physiopathology; Carcinoma, Non-Small-Cell Lung - physiopathology; Female; Gene Expression Regulation, Neoplastic; Histones - metabolism; HOX基因; Humans; Liver Neoplasms - physiopathology; Pancreatic Neoplasms - physiopathology; Polycomb Repressive Complex 2 - physiology; Review; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; 反义RNA; 基因调控; 癌变; 相互作用; 组蛋白H3; 过度表达; 非编码RNA; HOTAIR; cancer; lncRNA; carcinogenesis; metastasis

Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA （HOT...