Long non-coding RNA HOTAIR in carcinogenesis and metastasis
Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA （HOT...
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| Published in | Acta biochimica et biophysica Sinica Vol. 46; no. 1; pp. 1 - 5 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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China
Oxford University Press
01.01.2014
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| Abstract | Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA （HOTAIR）, a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 （PRC2） and regulates chromosome occupancy by EZH2 （a subunit of PRC2）, which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. |
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| AbstractList | Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress
HOXD
gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA （HOTAIR）, a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 （PRC2） and regulates chromosome occupancy by EZH2 （a subunit of PRC2）, which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. |
| Author | Jinsong Zhang Peijing Zhang Li Wang Hai-long Piao Li Ma |
| AuthorAffiliation | Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA |
| AuthorAffiliation_xml | – name: Department of Experimental Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, TX 77030 , USA |
| Author_xml | – sequence: 1 givenname: Jinsong surname: Zhang fullname: Zhang, Jinsong – sequence: 2 givenname: Peijing surname: Zhang fullname: Zhang, Peijing – sequence: 3 givenname: Li surname: Wang fullname: Wang, Li – sequence: 4 givenname: Hai-long surname: Piao fullname: Piao, Hai-long – sequence: 5 givenname: Li surname: Ma fullname: Ma, Li |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24165275$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author 2013. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. 2013 |
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| Notes | lncRNA; HOTAIR; cancer; metastasis; carcinogenesis 31-1940/Q Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA （HOTAIR）, a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 （PRC2） and regulates chromosome occupancy by EZH2 （a subunit of PRC2）, which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
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| Snippet | Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently... Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently... |
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| SubjectTerms | Animals Breast Neoplasms - pathology Carcinogenesis Carcinoma, Hepatocellular - physiopathology Carcinoma, Non-Small-Cell Lung - physiopathology Female Gene Expression Regulation, Neoplastic Histones - metabolism HOX基因 Humans Liver Neoplasms - physiopathology Pancreatic Neoplasms - physiopathology Polycomb Repressive Complex 2 - physiology Review RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics 反义RNA 基因调控 癌变 相互作用 组蛋白H3 过度表达 非编码RNA |
| Title | Long non-coding RNA HOTAIR in carcinogenesis and metastasis |
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